This paper proposes a new electronic-continuously variable transmission (E-CVT) system for power-split hybrid electric vehicles (HEVs). The key is to integrate two permanent magnet motor/generators (M/Gs) together with a coaxial magnetic gear (CMG). By designing the modulating ring of the CMG to be rotatable, this integrated machine can achieve both power splitting and mixing, and therefore, ca...

The replisome unwinds and synthesizes DNA for genome duplication. In eukaryotes, the Cdc45-MCM-GINS (CMG) helicase and the leading-strand polymerase, Pol epsilon, form a stable assembly. The mechanism for coupling DNA unwinding with synthesis is starting to be elucidated, however the architecture and dynamics of the replication fork remain only partially understood, preventing a molecular under...

The aim of this study was to develop a novel multifunctional nanoparticle, which encapsulates SPION and Gemcitabine in PLGA±PEG to form multifunctional drug delivery system. For this aim, super paramagnetic iron oxide nanoparticles (SPIONs) were synthesized and encapsulated simultaneously with Gemcitabine (Gem) in PLGA±PEG copolymers via W/O/W double emulsification method. Optimum size and enca...

The aim of this study was to develop a novel multifunctional nanoparticle, which encapsulates SPION and Gemcitabine in PLGA±PEG to form multifunctional drug delivery system. For this aim, super paramagnetic iron oxide nanoparticles (SPIONs) were synthesized and encapsulated simultaneously with Gemcitabine (Gem) in PLGA±PEG copolymers via W/O/W double emulsification method. Optimum size and enca...

Objective: Gemcitabine (GEM)-based combination chemotherapy has been studied to determine whether or not it improves outcomes, but results have generally been disappointing. We retrospectively compared chemotherapy with biweekly GEM plus a novel form of an oral 5-fluorouracil derivative (S1) (GEM+S-1) with GEM alone in locally advanced or metastatic pancreatic cancer. Patients and Methods: We s...

The cytoskeletal changes that alter cellular morphogenesis and motility depend upon a complex interplay among molecules that regulate actin, myosin, and other cytoskeletal components. The Rho family of GTP binding proteins are important upstream mediators of cytoskeletal organization. Gem and Rad are members of another family of small GTP binding proteins (the Rad, Gem, and Kir family) for whic...

Although the combination of cisplatin and gemcitabine (GEM) is considered the standard first-line chemotherapy against unresectable hilar cholangiocarcinoma (HC), its efficacy is discouraging. The present randomized open-label clinical trial aimed to evaluate the efficacy and safety of the GEM plus S-1 (GEM-S-1) combination against unresectable HC. Twenty-five patients per group were randomly a...

BACKGROUND Clinicians have difficulty accurately assessing medication non-adherence within chronic disease care settings. Health information technology (HIT) could offer novel tools to assess medication adherence in diverse populations outside of usual health care settings. In a multilingual urban safety net population, we examined the validity of assessing adherence using automated telephone s...

ANALYSIS OF A DUAL SCISSORED-PAIR,VARIABLE-SPEED,CONTROL MOMENT GYROSCOPE DRIVEN SPHERICAL ROBOTbyRICHARD CHASEMay 2014 Advisor: Dr. Abhilash PandyaMajor: Electrical EngineeringDegree: Doctor of Philosophy The objective of this research is to compare barycenter offset based designs of sphericalrobots to control moment gyroscope (CMG) based designs in order to determi...