Here we examined the involvement of insulin-like growth factor 1 (IGF-1) on chemotherapy-induced cognitive impairment. Sixty-four ovariectomized female Sprague-Dawley rats were included in the study and given cyclophosphamide, methothrexate, and 5-fluorouracil (CMF) drug combination or saline (control). CMF was given once a week for 4 weeks. In one experiment, behavioral testing using the cued ...

Chondromyxoid fibroma (CMF) is a rare benign cartilaginous tumor with a predilection for the bones of lower extremities and about one fourth of the tumors involve the foot.Radiologically, an eccentric lytic lesion with well defined margins is seen in the metaphysis of the bone. We hereby, report an 18 yr old young male who presented to Orthopedic Outpatient Department, JN Medical College, Aliga...

introduction: breast cancers are divided into at least 4 sub types on the basis of gene expression profiles and expression of receptors as measured by ihc (immunohistochemical). triple negative breast cancer (tnbc) is more chemosensitive yet, it is much harder to detect than other sub types. at present lack of highly effective therapeutic targets for tnbc, leaves standard chemotherapy, as the o...

Context. In our SCUBA survey of Perseus, we find that the fraction of protostellar cores increases towards higher masses and the most massive cores are all protostellar. Aims. In this paper we consider the possible explanations of this apparent mass dependence in the evolutionary status of these cores. We investigate the implications for protostellar evolution and the mapping of the embedded co...

The Highway Safety Manual [HSM, 2010] recommends safety evaluations be performed before implementing any roadway treatment to predict the expected safety consequences. Safety consequences can be measured using crash prediction models, Crash Modification Factor (CMFs), or both. This paper develops a CMF to show the expected impact of red-light cameras (RLCs) on safety at signalized intersections...

Purpose: The purpose of this study is to evaluate HER-2 and topoisomerase II (topo II ) as candidates for predicting the activity of anthracyclines in the adjuvant treatment of breast cancer patients. Experimental Design: In this study, we evaluated HER-2 and topo II gene aberrations by fluorescence in situ hybridization in a series of 430 primary breast cancer samples. Samples came from node-p...

BACKGROUND The optimal sequencing of chemotherapy and radiotherapy after breast surgery was largely studied but remains controversial. Concurrent chemo-radiotherapy is a valuable method for adjuvant treatment of breast cancer which is under ongoing research program in our hospital. We are evaluating the feasibility of the concomitant use of chemotherapy retrospectively. METHODS Two hundred fo...

Observations indicate that the central portions of the Present-Day Prestellar Core Mass Function (hereafter CMF) and the Stellar Initial Mass Function (hereafter IMF) both have approximately log-normal shapes, but that the CMF is displaced to higher mass than the IMF by a factor F ∼ 4±1. This has lead to suggestions that the shape of the IMF is directly inherited from the shape of the CMF – and...

Observations indicate that the central portions of the present-day prestellar core mass function (hereafter CMF) and the stellar initial mass function (hereafter IMF) both have approximately log-normal shapes, but that the CMF is displaced to higher mass than the IMF by a factor F ∼ 4 ± 1. This has led to suggestions that the shape of the IMF is directly inherited from the shape of the CMF – an...

introduction: mortality rate of breast cancer has been fallen in recent years. combination of cyclophosphamide, methotrexate, and 5-fluorouracil(cmf), as a pioneer of adjuvant chemotherapy of breast cancer, and later introduced anthracycline/taxane(a/t)-based regimens have both produced favorable outcomes in early-stage breast cancer. the current study, aimed to evaluate the probably different ...