In the current study, the effects of ethanol (EtOH) on toxicokinetics of methamphetamine (MA) and its metabolite amphetamine (AP) were investigated. A single dose of MA hydrochloride at 15 mg/Kg was given intragastrically, either alone (MA group; n = 8) or in conjunction with 3 g/Kg EtOH (MA+EtOH group; n = 8) to rabbits. In placebo group, normal saline only was given (placebo group; n = 4). Pl...

The aim of this study was to characterize the effect of typhoid fever on pharmacokinetic parameters of levofloxacin (LF) and compare the pharmacokinetic parameters of the said antibiotic in healthy human volunteers and patients with typhoid fever. Total of 12 subjects were divided into two groups “A” (healthy volunteers) and “B” (typhoid patients). Single oral dose of LF 500 mg was given and 5 ...

We present some results attained with two variants of Bounded Dynamic Programming algorithm to solve the Fm9block9Cmax problem using as an experimental data the well-known Taillard instances. We have improved the best known solutions for 17 of Taillard’s instances, including the 10 instances from set 12. & 2011 Elsevier Ltd. All rights reserved.

This paper presents a framework taking advantage of both the flexibility of constraint programming and the efficiency of operations research algorithms for solving scheduling problems under various objectives and constraints. Built upon a constraint programming engine, the framework allows the use of scheduling global constraints, and it offers, in addition, a modular and simplified way to perf...

OBJECTIVE To evaluate the bioavailability of vitamin D in capsules as compared with oily drops in nuns living in a closed community with very low sun exposure. METHODS A randomized, 2 x 2 crossover, open clinical trial was conducted, with 18 nuns aged between 20 and 75 years. Samples were collected in the fasting state and at 4, 8, 12 and 24 hours following the administration of capsules and ...

We present and apply a new simulation/optimization approach for singleand multiple-planning period problems in groundwater remediation. Instead of the traditional control locations for contaminant concentrations, \Ve use an LC>O norm as a global measure of aquifer contamination (CMAX). We use response-surface constraints to represent CMAX within the optimization model. We compare the performanc...

Methods: Fifteen extended-spectrum b-lactamaseor carbapenemase-producing E. coli were studied. The in vitro pharmacodynamic model was inoculated with 1×10 cfu/mL and ertapenem was dosed once daily at 0 and 24 h to simulate free ( f ) Cmax and t12 obtained after either 1 g or 2 g intravenous once-daily doses in healthy volunteers (1 g: f Cmax 15 mg/L, t12 4 h). Sampling was performed over 48 h t...

Аннотация For two scheduling problems (O3||Cmax and AL3||Cmax) tight bounds of the optima localization intervals are found in terms of lower bounds (C̃ and Ĉ, respectively) computable in linear time. The main part of the proof was made with an aid of computer. As a by-product, we obtain linear-time approximation algorithms for solving these problems with worst-case performance ratios 4/3 and 5/3...

For an odd prime p, an even integer n, and d = p + 1 with gcd(n, k) = 1, there are p + 1 distinct decimated sequences s(dt + l), 0 ≤ l < p + 1, for a p-ary m-sequence s(t) of period p − 1 since gcd(d, p − 1) = p + 1. In this paper, the cross-correlation distribution between a p-ary m-sequence s(t) and its p+1 distinct decimated sequences s(dt+ l) is derived. The maximum magnitude Cmax of their ...

The aim of this study was to prepare a nasal gel of risperidone and to investigate the pharmacokinetics and relative bioavailability of the drug in rats. Compared with oral dosing, the risperidone nasal gel exhibited very fast absorption and high bioavailability. Maximal plasma concentration (cmax) and the time to reach cmax (tmax) were 15.2 μg mL-1 and 5 min for the nasal gel, 3.6 μg mL-1 and ...