Designers work in teams to design complex systems. They separate the design problem into subproblems and solve the smaller, more manageable subproblems. Because this affects the overall quality of their design, it is important to understand how teams decompose system design problems, which will ultimately enable future research on how to design better design processes. We studied teams of exper...

We establish basic properties of cluster algebras associated with oriented bordered surfaces with marked points. In particular, we show that the underlying cluster complex of such a cluster algebra does not depend on the choice of coefficients, describe this complex explicitly in terms of “tagged triangulations” of the surface, and determine its homotopy type and its growth rate.

We establish basic properties of cluster algebras associated with oriented bordered surfaces with marked points. In particular, we show that the underlying cluster complex of such a cluster algebra does not depend on the choice of coefficients, describe this complex explicitly in terms of “tagged triangulations” of the surface, and determine its homotopy type and its growth rate.

Networks are a fundamental tool for understanding and modeling complex systems in physics, biology, neuroscience, engineering, and social science. Many networks are known to exhibit rich, lower-order connectivity patterns that can be captured at the level of individual nodes and edges. However, higher-order organization of complex networks--at the level of small network subgraphs--remains large...

Ferredoxins play an important role as an electron donor in iron-sulfur (Fe-S) cluster biosynthesis. Two ferredoxins, human mitochondrial ferredoxin 1 (FDX1) and human mitochondrial ferredoxin 2 (FDX2), are present in the matrix of human mitochondria. Conflicting results have been reported regarding their respective function in mitochondrial iron-sulfur cluster biogenesis. We report here biophys...

In oxidative phosphorylation, complex I (NADH:quinone oxidoreductase) couples electron transfer to proton translocation across an energy-transducing membrane. Complex I contains a flavin mononucleotide to oxidize NADH, and an unusually long series of iron-sulfur (FeS) clusters, in several subunits, to transfer the electrons to quinone. Understanding coupled electron transfer in complex I requir...

The synthesis and characterisation of a new, highly luminescent inorganic cluster complex, (Bu4N)2[Mo6I8(NO3)6], are described. The complex possesses labile nitrato ligands and is therefore a useful precursor for the design of new luminescent materials. To exemplify this, functionalised polystyrene beads have been utilised as "polymeric ligands" to immobilise the molybdenum cluster complex.