Sir, In the Guidelines for prophylaxis and treatment of methicillinresistant Staphylococcus aureus (MRSA) infections in the UK, the Joint Working Party states for empirical treatment that ‘The prevalence level at which flucloxacillin or other penicillinasestable penicillins, in a patient group, becomes no longer the drug of choice is debatable, but 10% resistance has been used as a guide for av...

BACKGROUND Neonatal sepsis contributes significantly to morbidity and mortality among young infants. The aetiological agents as well as their susceptibility to antimicrobial agents are dynamic. This study determined aetiology, antimicrobial susceptibility and clinical outcome of neonatal sepsis at Muhimbili National Hospital. METHODS Three hundred and thirty neonates admitted at the Muhimbili...

BACKGROUND Diagnosis of bloodstream infections (BSI) in neonates is usually difficult due to minimal symptoms at presentation; thus early empirical therapy guided by local antibiotic susceptibility profile is necessary to improve therapeutic outcomes. METHODS A review of neonatal blood cultures submitted to the microbiology department of the Korle-Bu Teaching Hospital was conducted from Janua...

Intramammary antibiotics are registered and tested for use in dairy cattle. This study investigated withdrawal periods of three intramammary antibiotics (Curaclox LC [Norbrook Pharmacia AH]), Spectrazol Milking Cow (Schering-Plough Animal Health) and Rilexine 200 LC (Logos Agvet [Virbac]) in dairy goats and compared them to withdrawal periods recommended for use in cattle. Three trials were car...

Seventy-one blood cultures were taken from 26 suspected cases of bacterial endocarditis. Antibiotic sensitivity pattern was determined in 29 positive cultures. Gentamycin was found to be the most effective. Cloxacillin, chloramphenic.o1,vibramycin, tetracycline, erythromycin were next in order (J PMA 33 87,1983).

Aginanthus brunneus is a specie of Africa mistletoe and is hemiparasitic in nature growing on many trees. Phytochemical screening showed the presence of carbohydrates, Alkaloids, Tannins and flavonoids. The ethanolic and aqueous extracts inhibited growth of Klesiella aerogenes, Proteus spp Escherichia coli, Pseudomonas aeruginosa. Gentamycin and Cloxacillin did not exhibit any activity against ...

A monoclonal antibody prepared against TEM-1 beta-lactamase was found to compete with penicillins and cephalosporins for binding to the enzyme. The purified antibody preparation was linked to Sepharose 4B and used for immunoaffinity-chromatography purification of TEM-1 beta-lactamase. Elution with either benzylpenicillin or cloxacillin yielded a highly purified, concentrated and active enzyme p...

Introduction: Cloxacillin is the second most prescribed antibiotic for skin and soft tissue infection in Malaysia. A similar pattern was seen Kuala Selangor, which our district demonstrated that Defined Daily Dose (DDD) of high (3.0-8.7) compared to recommended value from World Health Organization (WHO). However, resistant patterns are alarming. This study focuses on appropriate use prevent fur...