Methods We conducted an observational, retrospective study in two academic trauma centers from a French university institution. All patients diagnosed with HF on rotational thromboelastometry (ROTEM) between 2010 and 2014 were included. Demographic and clinical parameters, standard laboratory and ROTEM results were collected. HF diagnosis was established when the 60 minute clot lysis index (CLI...

Thrombelastography (TEG)/thromboelastometry (ROTEM) devices measure viscoelastic clot strength as clot amplitude (A). Transformation of clot amplitude into clot elasticity (E with TEG; CE with ROTEM) is sometimes necessary (eg, when calculating platelet component of the clot). With TEG, clot amplitude is commonly transformed into shear modulus (G; expressed in Pa or dyn/cm2) as follows: G = (50...

BACKGROUND Platelet-rich plasma is a fraction of plasma in which platelets are concentrated. It is reported to represent a source of multiple growth factors that promote tissue repair. In anticipation of the eventual testing of platelet-rich plasma in anterior cruciate ligament (ACL)-deficient patients, we examined the effect of autologous platelet-rich plasma on human ACL cell function in vitr...

In early diagnosis of typhoid fever, the emphasis has for long been on the isolation of S. typhi from blood culture. Clot culture techniques have not enjoyed the same vogue, although they are largely used in areas where the disease is endemic. Felix (1924) found that clot culture was hardly ever unsuccessful if blood culture was successful, but that the reverse was frequently true. He attribute...

Blood coagulation in vivo is a spatially nonuniform, multistage process: coagulation factors from plasma bind to tissue factor (TF)-expressing cells, become activated, dissociate, and diffuse into plasma to form enzymatic complexes on the membranes of activated platelets. We studied spatial regulation of coagulation using two approaches: 1), an in vitro experimental model of clot formation in a...

The purpose of this study was to establish the effects of clot age and thrombolysis, with either streptokinase or tissue-type plasminogen activator (tPA), on argatroban's ability to inhibit thrombin. The antithrombotic activity of argatroban has been quantified in fibrin clot permeation and fibrin clot perfusion systems as a function of clot age and composition. Analysis of the argatroban dose-...

OBJECTIVES Patients with peripheral artery disease have walking impairment, greater thrombotic risk, and are often treated with exercise training. We sought to determine the effect of a 3-month-long exercise program on clot strength among patients with peripheral artery disease and intermittent claudication. METHODS Twenty-three symptomatic peripheral artery disease patients were randomly ass...

OBJECTIVE This study aims to compare the clot stabilization on root surfaces conditioned with citric acid and ethylenediamine-tetraacetic acid (EDTA). MATERIALS AND METHODS Scaled root samples (n = 100) were set in fve groups: group I-control group (saline solution); group II (24% EDTA); group III (25% citric acid); group IV (EDTA + citric acid); group V (citric acid + EDTA). Fifty samples we...

Hemostasis is the process of blood clot formation and represents a coordinated response to vessel injury. It requires an orchestrated response from platelets, the clotting cascade, blood vessel endothelium, and fibrinolysis. Thrombin-stimulated clot formation and plasmin-induced clot lysis are closely related and regulated. This dynamic process is often viewed in phases: formation of a platelet...