Carbamazepine in the treatment of generalised tonic clonic seizures in juvenile myoclonic epilepsy Juvenile myoclonic epilepsy is characterised by bilateral myoclonic jerks on wakening, and generalised tonic clonic seizures with onset in the mid-teens, which may be preceded by typical absences in 33% of patients.' Findings on EEG include bilateral spikes or multiple spike-slow wave discharges a...

Serum phenytoin concentrations were monitored prospectively in 26 patients with previously untreated partial epilepsy, during monotherapy with phenytoin. Only six remained entirely seizure-free, although only four experienced further tonic-clonic seizures. There was no correlation between serum phenytoin concentrations and freedom from partial seizures in those patients in whom such seizures re...

Within the group of anticonvulsant drugs Carbamazepine (CBZ) is typically used in treatment seizure disorders. It applied partial, tonic-clonic and mixed seizures due to epilepsy or other reasons, neuropathic pain, certain mental This paper gives a quick overview pharmacological properties CBZ including its metabolism pathway CYP interactions.

Objective(s): Scientific interest in potential mobile phone impact on human brain and performance has significantly increased in recent years. The present study was designed to evaluate the effects of mobile phone radiation on seizure threshold in mice. Materials and methods:BALB/c male mice were randomly divided into three groups: control, acute, and chronic mobile phone radiation for 30, 60, ...

Orexin can increase neuronal excitability and induce epileptic activity. In this study, the effects of suvorexant (orexin receptor antagonist) on pentylenetetrazol (PTZ) and maximal electroshock (MES)-induced seizure were investigated. Mice were divided into 5 groups of six animals each including normal saline (10 ml/kg), diazepam (2 mg/kg) and suvorexant (50, 100 and 200 mg/kg) groups. In PTZ ...

Orexin can increase neuronal excitability and induce epileptic activity. In this study, the effects of suvorexant (orexin receptor antagonist) on pentylenetetrazol (PTZ) and maximal electroshock (MES)-induced seizure were investigated. Mice were divided into 5 groups of six animals each including normal saline (10 ml/kg), diazepam (2 mg/kg) and suvorexant (50, 100 and 200 mg/kg) groups. In PTZ ...

Objective(s): Anticonvulsant activity of phthalimide was discovered in 2000 by molecular hybridization of thalidomide and ameltolide. In our previous research we have reported some new 4-substituted derivatives of phthalimide with good activity against the tonic and clonic seizures Material and Methods: A series of novel 4-flurophthalimides that designed using bioisosteric replacement were synt...

OBJECTIVE The purpose of this article is to review the use of serum prolactin assay in epileptic seizure diagnosis. METHODS The authors identified relevant studies in multiple databases and reference lists. Studies that met inclusion criteria were summarized and rated for quality of evidence, and the results were analyzed and pooled where appropriate. RESULTS Most studies used a serum prola...