Conventional digital clock distribution interconnection causes a severe power consumption problem for GHz clock distribution because of transmission line losses, and it exhibits difficult signal integrity problems due to clock skew, clock jitter and signal reflection. To overcome these conventional digital clock distribution limitations, optical clock distribution techniques, based on guided-wa...

Abstract The symbiotic interactions between cancer stem cells and the tumor microenvironment (TME) are critical for progression. However, molecular mechanism underlying this symbiosis in glioblastoma (GBM) remains enigmatic. Here, we show that circadian locomotor output cycles kaput (CLOCK) its heterodimeric partner brain muscle ARNT-like 1 (BMAL1) glioma (GSCs) drive immunosuppression GBM. Int...

Crosstalk noise is a crucial factor affecting chip performance in deep submicron technologies. Among all possible crosstalk noise sources, clock is the most common aggressor as well as victim..Crosstalk on clock nets can increase clock jitter, which may degrade significantly the system performance. It is therefore imperative to design clock buffers to reduce the coupling effects. In this paper,...

Score-P is a measurement infrastructure originally designed for the analysis and optimization of the performance of HPC codes. Recent extensions of Score-P and its associated tools now also allow the investigation of energy-related properties and support the user in the implementation of corresponding improvements. Since it would be counterproductive to completely ignore performance issues in t...

The circadian clock regulates daily variations in physiologic processes. CLOCK acts as a regulator in the circadian apparatus controlling the expression of other clock genes, including PER1. Clock genes have been implicated in cancer-related functions; in this work, we investigated CLOCK as a possible target of somatic mutations in microsatellite unstable colorectal cancers. Combining microarra...

Over the past 20years, substantive research has firmly implicated the lateral habenula in myriad neural processes including addiction, depression, and sleep. More recently, evidence has emerged suggesting that the lateral habenula is a component of the brain's intrinsic daily or circadian timekeeping system. This system centers on the master circadian pacemaker in the suprachiasmatic nuclei of ...