CLINICAL PRACTICE GUIDELINES (CPGS) ARE WIDELY viewed as a cornerstone of current efforts to improve the quality of clinical care. At their best, CPGs articulate clear goals of care, enumerate potentially beneficial therapeutic approaches, and may reduce undesirable variation in care while supporting rational clinical management of common conditions. Clinical recommendations are often supported...

MR imaging has failed to assume the same importance as CT in the radiological evaluation of lung cancer. It is usually considered as an alternative modality when CT findings are inconclusive or as a primary modality in cases of contraindication to iodinated contrast media.1 Key reasons for the limited role of MRI relate to technical limitations, including longer scan times, inferior spatial res...

The potential for violence among hospitalized psychiatric patients is not a new phenomenon. Risk prediction in hospitalized psychiatric patients requires, in addition to actuarial tools, a firsthand understanding of the patient's psychiatric disorder, symptoms, personality structure, coping skills, and defense mechanisms. The current state of psychiatric hospital care and treatment of mental il...

This report reviews the evidence for and against clinical use of ambulatory blood pressure monitoring (ABPM) on a large scale. Such monitoring is supported by a number of data, among which is that the end-organ damage associated with hypertension correlates more with 24-h average blood pressure than with clinic blood pressure, the correlation becoming even closer with addition of blood pressure...

BACKGROUND International documents on ethical conduct in clinical research have in common the principle that potential harms to research participants must be proportional to anticipated benefits. The anticipated benefits that can justify human research consist of direct benefits to the research participant, and societal benefits, also called social value. In first-in-human research, no direct b...

BACKGROUND The expression of CD24 has been detected in a wide variety of human malignancies. Downregulation of CD24 inhibits proliferation and induces apoptosis in tumor cells, whereas its upregulation increases tumor growth and metastasis. However, no data on CD24 protein levels in retinoblastoma are available, and the mechanism of CD24 involvement in retinoblastoma progress has not been eluci...

The dominating mechanism for iron delivery to tissues is the internalisation of the transferrin receptor-diferric transferrin complex. Other ways for iron to enter cells exist but do not contribute significantly to the cellular iron homeostasis in humans. Once the complex has been endocytosed, iron is released to the cytosol for further transport inside the cell, for example to the mitochondria...