In order to achive best results in radiotherapeutic treatment of tumor tissue, one needs to precisely reconstruct the setup defined in therapy planning before the treatment can start. Inaccuracies in either defining the treatment parameters or transferring positioning markers to the patient’s body, errors in treatment device setup or patient motion during the treatment result in a displacement ...

The second part of the GYN GEC ESTRO working group recommendations is focused on 3D dose-volume parameters for brachytherapy of cervical carcinoma. Methods and parameters have been developed and validated from dosimetric, imaging and clinical experience from different institutions (University of Vienna, IGR Paris, University of Leuven). Cumulative dose volume histograms (DVH) are recommended fo...

We have proposed four dimensional (4D) digitally reconstructed radiography (DRR) for verifying a lung tumor position during volumetric modulated arc therapy (VMAT). An internal target volume (ITV) was defined based on two clinical target volumes (CTVs) delineated on maximum exhalation and maximum inhalation images acquired by 4D planning computed tomography (CT). A planning target volume (PTV) ...

Purpose In pancreatic cancer treatment, hyperthermia can be added to increase efficacy of chemo- and/or radiotherapy. Gas in stomach, intestines and colon is often close proximity the target volume. We investigated impact variations gastrointestinal gas (GG) on temperature distributions during simulated treatment (HT).Methods used sets one CT eight cone-beam (CBCT) scans obtained prior to/durin...

For prostate cancer radiotherapy, the interfractional organ motion can have several forms: changes in position, shape, and volume. The interfractional motion can be managed through either online or offline image guidance (IG). The position changes are commonly corrected through online IG by correcting couch position at each treatment fraction, while the shape and volume changes, or target defor...

Introduction: In radiation therapy of lung tumors, respiratory motion causes target moving, so a larger margin is needed to cover the clinical target volume (CTV). With the margin increasing, a larger volume of normal tissue will be exposed to high-dose.  In this study, dosimetric parameters of normal lung tissue were compared between gated and conventional radiotherapy (RT), u...

Helical tomotherapy (HT) can potentially be used for lung cancer treatment including stereotactic radiosurgery because of its advanced image guidance and its ability to deliver highly conformal dose distributions. However, previous theoretical and simulation studies reported that the effect of respiratory motion on statically planned tomotherapy treatments may cause substantial differences betw...

PURPOSE Evaluation of dose degradation by anatomic changes for head-and-neck cancer (HNC) intensity-modulated proton therapy (IMPT) relative to intensity-modulated photon therapy (IMRT) and identification of potential indicators for IMPT treatment plan adaptation. METHODS For 31 advanced HNC datasets, IMPT and IMRT plans were recalculated on a computed tomography scan (CT) taken after about 4...

Involvement of parametrial disease in locally advanced cervical patients poses a challenge for women undergoing brachytherapy. Current use of the Fletcher suit applicator may not adequately cover the high risk clinical target volume (HR CTV), especially in the parametrial region due to the physical qualities of brachytherapy from the inverse square law and the need to respect organs at risk (OA...