Supernumerary teeth (ST) are uncommon alterations of development that may appear in either of the dental arches and that are frequently associated with syndromes such as cleidocranial dysplasia and Gardner syndrome. Multiple ST in individuals with no other disease or syndrome are very rare. In view of this situation, correct diagnosis, treatment and evaluation of ST with the use of appropriate ...

Cleidocranial Dysplasia (CCD) or dysostosis is a very rare, under-diagnosed pathology caused by variable degree of expression dominant gene. It characterized skeletal malformations, which can be expressed in different clinical and imagenologic findings, with classic triad; late closure cranial sutures, hypoplasia aplasia clavicles dental abnormalities. We present case 46 years old male, no prev...

Cleidocranial dysplasia (CCD) is a rare autosomal dominant skeletal disease. CCD is caused by mutation in the gene on 6p21 encoding transcription factor CBFA1, i.e. runt-related transcription factor 2(RUNX2). The disease is characterized by a persistently open anterior fontanelle and skull sutures, hypoplastic or aplastic clavicles, dental abnormalities, short stature, a wide pubic symphysis, a...

Human growth and development of dentition generally follows an orderly pattern of an eruption sequence of primary dentition of 20 teeth, followed by an interim time of mixed dentition and concluding with 32 permanent teeth. The literature is rich with descriptions of variation of this pattern largely based on addition or deletion of the genetic code which may include geographic isolation and or...

The runt-related transcription factor 2 gene (RUNX2), which is also known as CBFA1, is a master regulatory gene in bone formation. Mutations in RUNX2 have been identified in cleidocranial dysplasia (CCD) patients. CCD is a rare autosomal dominant skeletal dysplasia that is characterized by delayed closure of cranial sutures, aplastic or hypoplastic clavicle formation, short stature, and dental ...