نتایج جستجو برای: cladribine

تعداد نتایج: 689  

Journal: :The Biochemical journal 2001
I Marzo P Pérez-Galán P Giraldo D Rubio-Félix A Anel J Naval

We have studied the role of caspases and mitochondria in apoptosis induced by 2-chloro-2'-deoxyadenosine (cladribine) in several human leukaemic cell lines. Cladribine treatment induced mitochondrial transmembrane potential (DeltaPsi(m)) loss, phosphatidylserine exposure, caspase activation and development of typical apoptotic morphology in JM1 (pre-B), Jurkat (T) and U937 (promonocytic) cells....

Journal: :American journal of physiology. Renal physiology 2009
Adam N Elwi Vijaya L Damaraju Michelle L Kuzma Delores A Mowles Stephen A Baldwin James D Young Michael B Sawyer Carol E Cass

This study examined the roles of human nucleoside transporters (hNTs) in mediating transepithelial fluxes of adenosine, 2'-deoxyadenosine, and three purine nucleoside anti-cancer drugs across polarized monolayers of human renal proximal tubule cells (hRPTCs), which were shown in previous studies to have human equilibrative NT 1 (hENT1) and 2 (hENT2) and human concentrative NT 3 (hCNT3) activiti...

2018
Giancarlo Comi Stuart Cook Kottil Rammohan Per Soelberg Sorensen Patrick Vermersch Abidemi K. Adeniji Fernando Dangond Gavin Giovannoni

Background The CLARITY and CLARITY Extension studies demonstrated that treatment of relapsing-remitting multiple sclerosis (RRMS) with cladribine tablets (CT) results in significant clinical improvements, compared with placebo. This paper presents the key magnetic resonance imaging (MRI) findings from the CLARITY Extension study. Methods Patients who received a cumulative dose of either CT 3....

2011
Svetlana Krstevska Sonja Genadieva-Stavric Tatjana Sotirova Dejan Spasovski Trajan Balkanov

Hairy cell leukemia (HCL) is a very rare type of leukemia, in which abnormal B lymphocytes, present in the bone marrow, spleen, and peripheral blood stream, get worse slowly or do not get worse at all. HCL is the disease where patients have pancytopenia with splenomegalia over 90% percent, palpable lymphadenopathy occur in 35% of patients, some form of serious infection eventually developed in ...

2012
Tatsuro Jo Masatoshi Matsuo Kensuke Horio Masao Tomonaga

Cerebral involvement frequently occurs in association with progression or relapse of malignant lymphoma. Chemotherapy with cyclophosphamide, doxorubicin, vincristine, and prednisolone, the standard chemotherapy for malignant lymphoma, is an ineffective treatment for cerebral involvement because these drugs cannot cross the blood-brain barrier. Therefore, various alternative strategies have been...

Journal: :Journal of Neurology, Neurosurgery & Psychiatry 2019

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