Cystinuria is an autosomal recessive disorder. Two genes responsible for cystinuria have been identified: SLC3A1 (chromosome 2p21) and SL7A9 19q12). Their mutations cause high clinical variability in the course of Over past 10 years, increase prevalence has observed, which now approximately 1:7,000 newborns. Similarly to cystic fibrosis, it one most common diseases with this pattern inheritance...

Although citrates are commonly used to modify nanoparticles, attention is rarely paid how the modification parameters affect type of adsorption and, thus, possibly, properties modified particles. The relevance this and significant impact it can have demonstrated in study by examining effect pH upon superparamagnetic iron oxide nanoparticles (SPIONs) with citrate, using a citrate concentration t...

Background: Nephrolithiasis is a common disorder with high rate of prevalence and recurrence without treatment. Urinary citrates, among others are important inhibitors of stone formation. The mean urinary citrate excretion is 640mg/d in healthy individuals. Hypocitraturia is a common metabolic abnormality detected in stone formers. Aim: To determine frequency of hypocitraturia among patients wi...

In a previous work we have demonstrated the antimicrobial activity of ferrocenyl or phenyl derivatives of diphenyl butene series. This finding has opened a new area of applications of organometallic compounds. In order to improve these activities, we have synthesized new organic and organometallic diaryl butene compounds with different lengths of their amino chains. These new compounds, and als...