Porcine circovirus-associated disease is caused by porcine circovirus type 2 (PCV2) infection, which targets iliac artery endothelial cells (PIECs); it leads to severe immunopathologies and is associated with major economic losses in the porcine industry. Here, we report that in vitro PCV2 infection of PIECs causes cell injury, which affects DC function as well as adaptive immunity. Specificall...

Porcine circovirus 2 (PCV2) is currently considered an important etiologic agent of swine and its infection has potentially serious economic impact on the swine industry worldwide. This virus is frequently associated with postweaning multisystemic wasting syndrome (PMWS), and also with other clinical conditions such as porcine dermatitis and nephropathy syndrome (PDNS), late-term abortions, rep...

Porcilis PCV is a biotechnology derived inactivated immunological veterinary medicinal product intended to be used for the active immunisation of pigs against Porcine Circovirus Disease (PCVD). First recognised in 1991 in Canada, Porcine Circovirus Type 2 (PCV2) is considered to be associated with a number of disease syndromes which have been collectively named PCVD. In particular, infection by...

Porcine circovirus type 2 (PCV2) is the necessary agent for the occurrence of post-weaning multisystemic wasting syndrome (PMWS) in pigs. It has been suggested that PMWS-affected pigs are immunosuppressed and, therefore, more prone to develop co-infections. In this study, we elucidated that PCV2 downregulates in vitro the immune cell functions during recall antigen responses. We showed that PCV...

Since the earliest days of biological product manufacture, there have been a number of instances where laboratory studies provided evidence for the presence of adventitious agents in a marketed product. Lessons learned from such events can be used to strengthen regulatory preparedness for the future. We have therefore selected four instances where an adventitious agent, or a signal suggesting t...

• Porcine Circovirus 2 vaccines are vital in preventing large-scale losses pig farms. There is a need to develop low-cost against the prevalent PCV2d strains. A vaccine candidate has been expressed at very high levels E. coli . An effective single-step chromatography protocol gives yields of over 1 g/L culture. The purified product possesses virus neutralising activity cell based assays. circov...

Porcine circovirus type 2 (PCV2) is considered by most to be the etiologic agent of postweaning multisystemic wasting syndrome (PMWS), but it is also found in association with numerous other conditions. These conditions include porcine dermatitis and nephropathy syndrome (PDNS), porcine respiratory disease complex (PRDC), congenital tremors (CT) type AII, reproductive failure and enteritis. Alt...

Porcine circovirus 3 (PCV3) is a recently emerged discovered in 2016 that has drawn the attention of swine industry worldwide. In this study, we evaluated genetic diversity PCV3 strains on pig farms. A total 261 samples from sows, weaning pigs, growing and stillborn/mummified fetuses were analyzed by quantitative real-time PCR. The results revealed at least two main lineages are circulating Bra...