Aims and Objectives: Assessment of renal toxicity profile of 177Lu-DOTATATE based Peptide Receptor Radionuclide therapy (PRRT) in patients of Metastatic Neuroendocrine tumor (NET) with a single functioning kidney. Materials and Methods: This was a retrospective analysis of NET patients, who had undergone PRRT with 177Lu-DOTATATE at a large tertiary care centre. The patients selected for the stu...

The present study is designed to evaluate the safety of aqueous: methanolic (40:60) extract Solanum xanthocarpum whole plant (SXWP) by determining its potential toxicity after acute and subacute administration in male wistar albino rats. Medicinal plants might deliver a few organic activities people, but generally very little known about their toxicity. Though, should be overriding criterion se...

background: chronic arsenic toxicity (arsenicosis) due to drinking of arsenic contaminated ground water is a global problem. however, its treatment is unsatisfactory. methylation of arsenic facilitates its urinary excretion. persons with relatively lower proportion of urinary dimethyl arsenic acid (dma) are found to have at greater risk of developing symptoms of arsenicosis including its compli...

In many organs of the human body, there are effective physiological barriers which contribute to regulation of the uptake, transport and secretion of endogenous and exogenous materials. ECVAM is involved in the development of several in vitro models for detecting damage to various barriers, for example, the renal epithelium, the intestinal barrier, and the blood-brain barrier, after acute and c...

In 1989, the guidance document for acutely toxic effluents entitled Methods for Aquatic Toxicity Identification Evaluations: Phase Ill Toxicity Confirmation Procedures was published (EPA, 19890). This new Phase Ill manual and its companion documents (EPA, 1991 A; EPA, 1992; EPA, 1993A) are intended to provide guidance to aid dischargers in confirming the cause of toxicity in industrial and muni...