BACKGROUND Thermal injury is associated with several biochemical and histopathological alteration in tissue. Analysis of these objective parameters in research and clinical field are common to determine healing rate of burn wound. Negative pressure wound therapy has been achieved wide success in treating chronic wounds. This study determines superficial burn wound healing with intermittent n...

Exudate can be an excellent indicator of what is happening within a wound and, therefore, provides valuable information during patient assessment. The volume, consistency, and particularly odour and colour, of any exudate will inform the practitioner about bacterial contamination, infection and stage of healing (Hampton and Collins, 2003). However, in the chronic wound, exudate must be effectiv...

silymarin, an extract from silybum marianum, has been shown to have antioxidant properties. however, there is no scientific report on wound healing activity of the silymarin. the purpose of this study was to evaluate the effect of topical administration of silymarin on excision wound healing in rats. excision wounds were made on the back of rats. rats were divided into three groups, as control,...

background: in developing new products for skin care and wound treatment, biocompatibility plays a major role in the choice of ingredients. thymol, an essential oil extracted from thyme plant, exhibits outstanding antibacterial properties, but more importantly, it proves to be much more compatible to skin cells in comparison to some conventionally used antibiotic drugs and chemicals. objective:...

However, disparate reports in the literature contradict the described beneficial effects of ATRA on wound healing. For example, Kitano et al.17 reported a non-significant effect of ATRA on wound closure in normal mice, but a significant increase in closure in diabetic mice. Furthermore, the continuous treatment of wounds with ATRA, inhibited re-epithelisation18, disrupted collagen production an...

During the recent years several non-pharmaceutical treatments have been proposed as alternative or adjunctive treatment for chronic wounds. Low level laser therapy (LLLT) is a new technique used for the treatment of wounds. The present study reviews the most current laser radiation based methods for wound treatments and clinical considerations for the different wounds. In addition, the proposed...

The authors review the existing physical modalities for treatment of chronic wounds and show the advantages of electric current and electromagnetic field stimulation. Direct currents, low frequency pulsed currents, monophasic high voltage pulses and pulsed electromagnetic fields are compared in respect of their efficiency. Wound healing quantification methods, wound healing dynamics and prognos...

Chronic, non-healing wounds are a major complication of diabetes. Recently, various cell therapies have been reported for promotion of diabetic wound healing. Epidermal stem cells (ESCs) are considered a powerful tool for tissue therapy. However, the effect and the mechanism of the therapeutic properties of ESCs in the diabetic wound healing are unclear. Herein, to determine the ability of ESCs...