Objective: Atorvastatin has the pleiotropic effects, including anti-inflammation and antioxidant. Therefore, this study considered to examine the effects of atorvastatin on NF-қB expression, as a main transcription factor for expression of inflammatory cytokines, in hyperglycemia-induced nephropathy in rat. Materials and Methods: Twenty four male Wistar rats were randomly divided into four g...

  Diabetes mellitus is the most common cause of chronic renal disorders and end-stage kidney disease in developed countries. It is the major cause of dialysis and transplantation. Failure in renal function causes wide disorders in the body. Diabetes results in wide range of alterations in the renal tissue. It is believed that early histological changes in diabetic nephropathy are detectabl...

BACKGROUND Calcium oxalate nephropathy is rare in current practice. It was a common complication during jejunoileal bypass, but much less seen in modern gastric bypass surgery for morbid obesity. The major cause of it is enteric hyperoxaluria. CASE PRESENTATION We report on a patient here with acute kidney disease due to calcium oxalate nephropathy, rather than the conditions mentioned above....

Background and aims: Diabetic nephropathy (DN) is the most common cause of end-stage renal failure which could increase the risk of cardiovascular disease and morbidity and mortality in patients. The aim of this study was to investigate new modalities for treatment of diabetic nephropathy. Methods:This study was a mini-review research to investigate drugs that are used for DN treatment. Resul...

BACKGROUND Various renal manifestations are known to develop in patients with liver disease, including chronic hepatitis and cirrhosis. CASE PRESENTATION We evaluated renal disease in two 47-year-old Japanese men with liver cirrhosis and chronic alcoholism for 34 years and 27 years, respectively. Renal biopsy demonstrated massive wire loop-like deposits in the subendothelial space of the glom...

Polyomavirus type BK-associated nephropathy (BKVAN) develops from reactivation of latent infection in urothelium and kidney tubular epithelium. While BK viremia may occur a variety immunosuppressed states, BKVAN exclusively allografts. We report case middle-aged man with remote history allogeneic hematopoietic stem cell transplant (HSCT) who had chronic disease (CKD) secondary to BKVAN.

BACKGROUND Lithium (Li) is an invaluable drug for the treatment of bipolar disorder. Long-term Li use is associated with renal complications including the formation of uncomplicated renal cysts caused by proliferation and expansion of collecting duct (CD) cells. We report six patients with complicated renal cysts in the context of Li nephropathy. METHODS Over a time period of 15 years, we hav...

The relationship of weight gain to survival, risk of development of chronic progressive nephropathy and risk of development of various neoplasms has been studied in the control groups from two routine chronic toxicity studies in Sprague-Dawley rats. The groups comprised 100 CFY strain rats of each sex observed up to the age of 109 wk and 120 CD strain rats of each sex observed up to 11 1 wk of ...

The involvement of the Notch signaling pathway in the cellular differentiation of the mammalian kidney is established. Recently, the dysregulation of Notch signaling molecules has been identified in acute and chronic renal injuries, fibrosis models, and diabetic kidney biopsies. The canonical Notch ligand , Jagged1, is upregulated in a transforming growth factor-beta- (TGF- β -) dependent manne...

Citation: Woo KT, Chan CM, Choong HL, (2017) A Novel Therapy for Diabetic Nephropathy. J Nephrol urol. Vol. 1 No. 1: 2 The ISN (International Society of Nephrology) Global Outreach Programme confirmed that for the less developed countries, compared to the more developed ones, Chronic Glomerulonephritis (Chronic GN) and not Diabetic Nephropathy (DiabNx) is still the leading cause of end stage re...