Cutaneous leishmaniasis is acquired from the bite of an infected sand fly and can result in chronic skin lesions that develop within weeks to months after a bite. Local trauma has been implicated as a precipitating event in the development of skin lesions in patients who have been infected with Leishmania species. Here we report a case series and review the literature on patients who developed ...

Chronic microbial infections are associated with fibrotic and inflammatory reactions known as granulomas showing similarities to wound-healing and tissue repair processes. We have previously mapped three leishmaniasis susceptibility loci, designated lmr1, -2, and -3, which exert their effect independently of T cell immune responses. Here, we show that the wound repair response is critically imp...

objective(s):in this study, the serum level of interferon-γ (ifn- γ) and interlukin-4 (il-4) was evaluated as a marker of th1 and th2 immune response that influence the clinical course of cutaneous leishmaniasis[r1] . materials and methods: this cross-sectional study was conducted on 44 cases of cutaneous leishmaniasis (21 cases with healed lesions and 23 cases with chronic non-healing lesions....

Sir, Histological examination of the affected skin showed a granuloma consisting of lymphocytes, plasmacytes and, mostly, A 68-year-old man, on pharmacological substitution therapy for 10 years for the removal of a large pituitary adenoma with histiocytes. The routine blood work-up and the lymphocytic subpopulation assays resulted as normal. asymmetric expansion above the cella turcica, present...

Cutaneous leishmaniasis caused by leishmania tropica is endemic in Iran. Kerman is the fifth most infected foci of dry type of cutaneous leishmaniasis after Tehran, Mashhad, Naishabor and Shiraz. We studied the clinical features of this disease in 664 patients referred to the dermatology and private clinic during the period March 1992 to March 1993 in Kerman. Females were dominated. The d...

Neglected tropical diseases encompass a group of chronic and debilitating infectious that primarily affect marginalized populations. Among these diseases, leprosy leishmaniasis are endemic in numerous countries can result severe disfiguring manifestations. Although there have been reports indicating higher incidence males, the underlying factors contributing to this observation remain unclear. ...

OBJECTIVE(S) In this study, the serum level of interferon-γ (IFN- γ) and interlukin-4 (IL-4) was evaluated as a marker of Th1 and Th2 immune response that influence the clinical course of cutaneous leishmaniasis . MATERIALS AND METHODS This cross-sectional study was conducted on 44 cases of cutaneous leishmaniasis (21 cases with healed lesions and 23 cases with chronic non-healing lesions. Th...