BACKGROUND Increased hepatic iron is assumed to potentiate progression towards liver fibrosis in chronic hepatitis C virus (HCV) infection. In this study we have evaluated the potentiating effect of marked hepatic iron overload and chronic HCV infection on hepatic fibrosis in thalassemic patients. METHODS Liver biopsies of one group of patients with beta thalassemia major and chronic HCV infe...

objectives: patients with hepatitis c virus infection are at high risk of getting hepatitis a virus. hepatitis a virus is an important widespread virus that usually causes more severe medical consequences in patients with chronic liver disease. the purpose of this study was to evaluate prevalence of hepatitis a virus antibody in patients with chronic hcv in isfahan province, iran. methods: a cr...

OBJECTIVE To determine the prevalence, target antigens and clinical associations of antineutrophil cytoplasmic antibodies (ANCA) in chronic hepatitis C without extrahepatic manifestations and in chronic hepatitis C virus (HCV)-associated mixed cryoglobulinemia (MC) in two European centers. METHODS 50 sera from patients with chronic hepatitis C and 116 sera from HCV-associated MC were tested f...

Background. Red cell distribution width (RDW) and platelet-lymphocyte ratio (PLR) have been studied in a variety of etiological diseases. We aim to investigate the relationship between RDW and PLR and the severity of hepatitis C virus- (HCV-) related liver disease. Methods. We included fifty-two chronic HCV and 42 HCV-related cirrhosis patients and 84 healthy controls. Hematological and virolog...

Hepatitis C virus (HCV) is one of the leading causes chronic liver disease. Hepatocellular carcinoma (HCC) a major complication associated with HCV infection, significant mortality and morbidity rates. This study aimed to measure biochemical parameters RNA levels for detection severity hepatitis virus- hepatocellular carcinoma. The was conducted on 100 patients, ages ranging from 36 68 years p...

We detected an antibody to HCV envelope protein (E1) in sera of patients with HCV-related chronic liver diseases (20 patients with chronic hepatitis and 5 patients with liver cirrhosis) by Western blotting using the fusion protein of E1 envelope protein and beta-galactosidase as an antigen. The antibody to HCV E1 (anti-HCV E1) was detected in 8 (42%) of 19 patients positive for HCV-RNA (16 were...

Hepatitis C virus (HCV) is a major public health problem with more than 130-180 million people infected worldwide. Several studies in different populations have reported the association of human leukocyte antigen (HLA) genotypes, and HCV viral load, and genotypes. The aim of this study was to investigate a possible association between HLA class I and II alleles in HCV-infected patients and heal...

Hepatitis C virus (HCV) infects more than 170 million people worldwide and around 20% of blood donors are seropositive by ELIZA to HCV Ab in Egypt. Renal manifestations may be the presenting features of chronic HCV infection. This work was carried out on 200 patients with chronic HCV in order to study the relationship between HCV and chronic kidney Disease and to stratify HCV patients according...

BACKGROUND Although hepatitis C virus (HCV) infection is a possible pathogenetic factor for intrahepatic cholangiocarcinoma (ICC), clinicopathologic features of ICC patients with HCV infection remain unclear. PATIENTS AND METHODS Of 50 patients with ICC treated, 19 were infected with HCV (HCV-positive group) and 38 underwent surgical treatment. Clinicopathologic features and postoperative out...

Liver disease secondary to chronic hepatitis C virus (HCV) infection is an important cause of morbidity and mortality in dialysis patients and kidney transplant recipients. Evaluation of patients with chronic HCV infection is warranted to determine stage of disease and the need for HCV therapy. Although combination therapy with interferon (IFN) plus ribavirin is the standard of care for chronic...