Brucellosis is a common zoonotic disease that remains endemic in many parts of the world. Dissecting the host immune response during this disease provides insight as to why brucellosis is often difficult to resolve. We used a Brucella epitope specific in vivo killing assay to investigate the ability of CD8+ T cells to kill targets treated with purified pathogenic protein. Importantly, we found ...

BACKGROUND Brucellosis is a major public health problem in developing countries and has remained endemic in Iran. The aim of this study was to investigate the Seroprevalence of Brucellosis among high risk individuals in Guilan, Iran. METHODS In a cross-sectional study, 478 blood samples from people living in rural areas (n = 292) and 186 slaughterhouse workers were screened by slide agglutina...

Abstract Brucellosis remains a public health problem in many Mediterranean countries. In this work are presenting data of human brucellosis clinics and treatment sample hospitalized patients. Methods: All patient charts at regional hospital Gjirokastra, Albania were systematically reviewed, during the period 2016-2021. patients with laboratory confirmed diagnoses included study. Variables inter...

background brucellosis is a systemic bacterial disease transmitted from animals to humans and involves many organs and tissues. symptoms of brucellosis are protean and can be similar to many other infectious diseases. none of the symptoms are specific enough to support the clinical diagnosis. the musculoskeletal system is one of the most commonly affected organs. disease can be present with bur...

Brucellosis is primarily an animal disease, and in them it passes as an asymptomatic chronic infection. In humans, brucellosis can be acute, sub-acute and/or chronic disease, but its geographical distribution follows the pattern found in animals. After the last war, the first Brucella cases in Bosnia and Herzegovina were reported in 2000, in returnees, owners of donated livestock. The objective...

introduction headache is a common complaint in children, and it has a significant effect on their daily living activities. having a definite diagnosis for the cause of the headache is very important for its appropriate management. case presentation we report a 12-year-old boy complaining of chronic headache, with a positive family history of migraine. the only abnormal finding in his general an...

BACKGROUND Neurobrucellosis is an uncommon complication of brucellosis. The clinical features of neurobrucellosis vary greatly and, in general, tend to be chronic. Many of the laboratory procedures usually employed in the diagnosis of brucellosis frequently give negative results. For these reasons, and because brucellosis is a disease, which is both treatable and curable, the degree of suspicio...

BACKGROUND Brucellosis is a worldwide and zoonotic disease often sadly misdiagnosed in endemic areas. Challenges of availability and accessibility of diagnostic tools are common in resource constrained populations where the most vulnerable are found, surveillance and diagnosis are limited too. METHODS A cross-sectional study using a simple two stage cluster sampling method was conducted to me...