BACKGROUND Hyperuricemia is an independent risk factor of nephropathy, but its role in renal transplant recipients (RTRs) is controversial. METHODS Based on the methods of Cochrane systematic reviews, we searched MEDLINE (1948-2011.6), EMBASE (1956-2011.6), CBM (Chinese Biomedicine Database) (1978-2011.6) to identify cohort studies assessing the association between uric acid level and kidney ...

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1. Uppin MS, Prayaga AK, Murty KV. Utility of renal allograft biopsy: An audit of 80 allograft biopsies. Indian J Nephrol 2013;23:155‐6. 2. Kazi J, Mubarak M. Biopsy findings in renal allograft dysfunction in a live related renal transplant program. J Transplant Technol Res 2012;2:108. 3. Racusen LC, Colvin RB, Solez K, Mihatsch MJ, Halloran PF, Campbell PM, et al. Antibody‐mediated rejection c...

Chronic antibody-mediated rejection (cAMR), one of the main causes of late allograft loss, was suggested as a new disease entity for the first time in 2001 [1]. This study showed that a significant proportion of chronic rejection cases are mediated by alloantibodies, and C4d positivity can separate these cases from non-specific chronic allograft nephropathy [2]. Another study reported that comp...

Chronic allograft nephropathy (CAN), a descriptive term denoting chronic scarring injury of the renal parenchyma and vasculature in allograft kidneys arising from various etiologies including chronic rejection, is the most common cause of late allograft failure, but mediators of this progressive injury largely remain unknown. We hypothesized that platelet-derived growth factor D (PDGF-D) and it...

Background: After the first year of transplantation chronic allograft nephropathy is the most important cause of renal graft loss and hypertension and proteinuria occur commonly. In native nephropathies, proteinuria and progression to renal failure are linked and renal tubulo-interstitial fibrosis determines prognosis. Monocyte chemoattractant protein-1 (MCP-1) is a powerful chemokine promoting...