Metaphase chromosome preparations were analysed as part of a larger study from a population occupationally exposed to benzene and compared with a control group. Forty eight of the 66 exposed individuals and 29 of the 33 controls had samples in which metaphase spreads could be evaluated. The incidence of chromosomal aberrations (particularly chromatid deletions and gaps) in the exposed group wer...

is well established that the irradiation of cells at any stage in development 'Tduring interphase results in the formation of chromosome aberrations, but that two basically different types of chromosome changes may be produced. Aberrations induced in roots of Vicia faba exposed to 50 rads of X rays are first seen in metaphase cells at about 2 hours after irradiation. In those cells which reach ...

Research on sex chromosome aberrations has made considerable progress. There are evidences that possession of an extra X chromosome may affect the mental health of an individual. All the male schizophrenia patients registered during the period of study, who were not under treatment, constituted the patient sample. They numbered two hundered eighty seven. A properly matched control sample of two...

Most mutagens and genotoxic carcinogens are efficient inducers of chromosomal alterations in exposed cells. Two important classes of aberrations, namely structural and numerical, are recognized and both types of aberrations are associated with congenital abnormalities and neoplasia in humans. These alterations can be easily detected and quantified in human peripheral blood lymphocytes. Conventi...

T has been known for some time that there are differences in the radiationI induced chromosomal aberrations observed at metaphase, according to the stage of the cell cycle the cells were in at the time of irradiation (SWANSON 1957). The observed differences are not only quantitative (changes in frequency per cell), but are also qualitative in that, depending on the stage and the chromosomal stm...

A chromosome analysis was performed on cultured bone marrow fibroblasts (CFU-F) from two atomic bomb survivors exposed within 1 km of the hypocenter, whose estimated radiation dose is 357 rad and 365 rad respectively. In CFU-F of both cases, stable types of chromosome aberrations were detected. The rate of these chromosome aberrations related well to the chromosome aberration rate of peripheral...

Various nonrandom chromosomal aberrations have been identified in prostate carcinoma. These aberrations include deletions of several chromosome regions, particularly the chromosome 8 short arm. Large-scale numerical aberrations, reflected in aberrant DNA ploidy, are also found in a minority of cases. However, it is unclear whetherprostate carcinomas contain aberrations of certain chromosome reg...

Although relatively rare, leukemias place a considerable financial burden on society and cause psychologic trauma to many families. Leukemia is the most common cancer in children. The causes of leukemia in adults and children are largely unknown, but occupational and environmental factors are strongly suspected. Genetic predisposition may also play a major role. Our aim is to use molecular epid...

Long-lived, sensitive, and specific biomarkers of particular mutagenic agents are much sought after and potentially have broad applications in the fields of cancer biology, epidemiology, and prevention. Many clastogens induce a spectrum of chromosome aberrations, and some of them can be exploited as biomarkers of exposure. Densely ionizing radiation, for example, alpha particle radiation (from ...

BACKGROUND & OBJECTIVE Myelodysplastic syndrome (MDS) represents a group of clonal haematological disorders characterized by progressive cytopenia reflecting defects in erythroid, myeloid and megakaryocytic maturation. The incidence of MDS is more in older age groups and frequent chromosome abnormalities reported to be monosomies 5 and 7. However, the data on cytogenetic changes in Indian MDS p...