This scoping paper was prepared primarily to provide background information to members of the Study Team on key issues related to the design of an European emissions trading scheme and to assist the "brainstorming" process. The views expressed in this paper are not necessarily those of CCAP who do cannot accept responsibility for the completeness or accuracy of the information and analysis cont...

A few examples of models of chromosome aberration induction are summarised and discussed on the basis of the three main theories of aberration formation, that is "breakage-and-reunion", "exchange" and "one-hit". A model and code developed at the Universities of Milan and Pavia is then presented in detail. The model provides dose-response curves for different aberration types (dicentrics, transl...

Non Hodgkin’s Lymphoma (NHL) or Lymphoma is a cancer that affects the lymphocytes of the immune system and present as a solid of lymphoid cell mass. Genetic disorder is one of the important factors for development NHL .The present study of bone marrow sample includes 65 NHL patients (46 male and 19 female) Chromosome analysis demonstrated that about 73.84 % of metaphase plate of NHL patients sh...

In an attempt to understand better the molecular basis of chromosome aberration formation, neocarzinostatin (NCS)-induced damage and repair were compared at the chromosome and DNA levels. Chromosome damage and repair in quiescent normal human fibroblasts (PA2 and DET 550) were assayed by the premature chromosome condensation technique in which the G1 prematurely condensed chromosomes are conden...

FLT3 (fms-related tyrosine kinase 3) with tandem internal duplication (ITD) is a known adverse prognostic factor in normal karyotype acute myeloid leukemia (AML). Since we recently observed several patients with trisomy 8 (+8) and FLT3 positivity, we asked whether FLTD ITD carried any prognostic significance in sole trisomy 8. Trisomy 8 is the most frequent numerical aberration in AML, occurrin...

Dose-rate effects on chromosome aberrations in the low-dose-rate range have not been evaluated previously. The incidences of chromosome aberrations were analysed in splenic lymphocytes from female specific pathogen-free (SPF) C3H mice that were continuously irradiated with low- or medium-dose-rate (LDR, MDR) (137)Cs γ rays from 56 days of age to evaluate the dose-rate effects. The dose-response...

Recurrent chromosome aberrations are an important resource when associating human pathologies to specific genes. However, for technical reasons a large number of chromosome breakpoints are defined only at the level of cytobands and many of the genes involved remain unidentified. We developed a web-based information system that mines the scientific literature and generates textual and comprehens...

Several environmental pollutants can cause damage to chromosomes, one of which is the heavy metal NiNO3. Some plant extracts have antigenotoxic properties that result in a decrease chromosomal damage. Member flowering plants need be tested seagrass. One seagrass species Enhalus acoroides was found contain phytochemical compounds. This study aimed analyse genotoxic effect and potential encapsula...