Various types of DNA damage, induced by endo- and exogenous genotoxic impacts, may become processed into structural chromosome changes such as sister chromatid exchanges (SCEs) and chromosomal aberrations. Chromosomal aberrations occur preferentially within heterochromatic regions composed mainly of repetitive sequences. Most of the preclastogenic damage is correctly repaired by different repai...

Chromosomal anomalies remain the commonest cause of mental retardation and congenital malformation. Traditionally, the prenatal diagnosis of chromosomal aberration relies on cytogenetic analysis of the cells obtained from amniocentesis or chorionic villus sampling (CVS). First, the amniotic fluid or chorionic villi samples need to be cultured for 14 days or more before adequate foetal cells can...

chromosomal abnormalities are major causes of infertility, miscarriage and birth of handicapped progeny. in human live births, the prevalence of a chromosome aberration is ?0.5% and, of these, 0.1–0.3% correspond to structural chromosome rearrangements such as translocations, inversions, insertions and deletions .our proband is an infant who had died 4 hours after birth due to a variety of abno...

Chromosomal aberration and sister chromatid exchange (SCE) frequencies were determined in lymphocytes cultured from 12 high-risk individuals working at a landfill for hazardous waste disposal. Cell proliferation kinetics (CPK) was also determined. Compared with 7 control individuals, no effects were observed with respect to SCE nor on CPK. However, the workers exhibited significantly higher fre...

Background: Radiotherapy is regarded as a standard treatment modality in breast cancer (BC). Radiation causes cellular damage both in cancer and normal cells by inducing DNA-damage and chromosomal aberrations (CA). Different agents were used for ameliorating effects of radiation, mainly antioxidants such as melatonin. Melatonin shows oncostatic properties on human BC. The aim of this study was ...

IntroductionOperating room workers are at risk of experiencing adverse effects due to occupational exposure waste anesthetic gases (WAGs). One the consequences long-term WAGs is probability developing deoxyribonucleic acid (DNA) damage. This systematic review investigated link between and DNA damage in operating workers.MethodsPubMed, Science Direct, ProQuest, Scopus, EbscoHost, as well hand-se...

AIMS Congenital heart defects (CHDs) are frequently caused by chromosomal imbalances, especially when associated with additional malformations, dysmorphism, or developmental delay. Only in a subset of such patients, a chromosomal aberration can be identified with current cytogenetic tests. Array Comparative Genomic Hybridization (Array-CGH) now enables the detection of submicroscopic chromosoma...