In cell nuclei, molecular structures called chromatin may play a role in the formation of droplets that are crucial for many cellular functions.

Abstract Emerging studies show that testis-enriched genes play critical roles in several biological processes. The expression of these is tightly regulated and limited to immune-privileged organs; however, many them escape regulation are aberrantly expressed diseases such as cancer. Intriguingly, our genomic analysis revealed transcribed from previously considered gene deserts. We also found a ...

Bone-marrow mesenchymal stem cell (BM-MSC) proliferation and lineage commitment are under the coordinated control of metabolism epigenetics; MSC niche contains low oxygen, which is an important determinant cellular metabolic state. In turn, drives fate decisions via alterations chromatin landscape. Due to fundamental role BM-MSCs in development adipose tissue, bones cartilage, age-associated ch...