PURPOSE It may be possible to restore accommodation to presbyopic human eyes by refilling the lens capsular bag with a soft polymer. In the present study, optical changes were measured that occurred in a pig eye model after the refilling of the capsular bag. METHODS The optical power and spherical aberration in 10 isolated pig lenses were measured under different conditions. They were first d...

In embryonic and adult lenses, a balance of cell proliferation, cell cycle exit, and differentiation is necessary to maintain physical function. The molecular mechanisms regulating the transition of proliferating lens epithelial cells to differentiated primary lens fiber cells are poorly characterized. To investigate this question, we used gain- and loss-of-function analyses to modulate fibrobl...

PURPOSE To assess and compare the effects of contact lens-based artificial pupil design and contralateral balanced multifocal contact lens combination (CBMCLC) on visual performance. METHODS This randomized crossover study conducted at the University of Valencia, Spain included 38 presbyopic patients using an artificial pupil contact lens in the nondominant eye and a CBMCLC. After a month of ...

We present the first automated spectroscopic search for disk-galaxy lenses, using the Sloan Digital Sky Survey database. We follow up eight gravitational lens candidates, selected among a sample of ∼ 40000 candidate massive disk galaxies, using a combination of ground-based imaging and long-slit spectroscopy. We confirm two gravitational lens systems: one probable disk galaxy, and one probable ...

PURPOSE To determine the role of the actin cytoskeleton regulatory proteins tropomyosin and tropomodulin (Tmod) in the reorganization of the actin cytoskeleton during lens epithelial cell differentiation. METHODS Primary cultures of chick lens epithelial cells were allowed to differentiate in vitro to form lentoid bodies. Localization of F-actin, Tmod, and tropomyosin were determined by immun...

As is known, lens fibers have not only various forms of protoplasmic processes at each edge but also wall spines on the surface of the lens fiber, and they interdigitate tightly with the adjacent lens fibers in fixed manners of interdigitation (FUTAGAMI, 1962; TANAKA and IINO, 1967; MATSUURA and WATANABE, 1968). Moreover, it has been suggested that each species has some similar characteristics ...

PURPOSE Retinal ischemia appears to lead to alterations in retinal transcript levels of a group of genes known to be abundantly expressed in the lens. Our purpose is to study whether these alterations are truly the result of retinal ischemia or whether they could be caused by contamination of the retinal tissue with trace amounts of lens tissue. METHODS Changes occurring in the retinal gene e...