Introduction: Choline uptake and metabolism is decreased in older adults. A decrease in cholinergic function is characteristic of both normal aging and agerelated diseases (e.g., Alzheimer disease). Interestingly, the intensity of the signal at 3.2 ppm in lH-MRS (“choline” signal) serves as a marker for several brain pathologies including brain tumors. This chemical shift is indicative of the N...

1. Injection of [Me-14C]choline into sheep indicated that the small amount of phosphatidylcholine present in abomasal digesta was largely (69%) of non-dietary or ruminal origin. 2. Long-term feeding of [Me-3H]choline to sheep produced insignificant labelling of plasma phosphatidylcholine, indicating that more than 99% of the choline body pool was of non-dietary origin. 3. In contrast, when rats...

PURPOSE We compared the accuracy of (18)F-Choline-PET/MRI with that of multiparametric MRI (mMRI), (18)F-Choline-PET/CT, (18)F-Fluoride-PET/CT, and contrast-enhanced CT (CeCT) in detecting relapse in patients with suspected relapse of prostate cancer (PC) after external beam radiotherapy (EBRT). We assessed the association between standard uptake value (SUV) and apparent diffusion coefficient (...

Recently, choline has been associated with neurodevelopment, cognitive function and neural tube defect incidence. However, data on usual intakes are limited, and estimates of dietary intakes of choline and its metabolite betaine, are not available for New Zealanders. The objective of the present study was to determine usual intake and food sources of choline and betaine in a group of New Zealan...

Phosphatidylcholine (PC), a common phospholipid of the eukaryotic cell membrane, is present in the cell envelope of the intracellular pathogen Brucella abortus, the etiological agent of bovine brucellosis. In this pathogen, the biosynthesis of PC proceeds mainly through the phosphatidylcholine synthase pathway; hence, it relies on the presence of choline in the milieu. These observations imply ...

Choline is essential for synthesis of the major membrane phospholipid phosphatidylcholine. Moreover, it serves as a precursor for synthesis of the neurotransmitter acetylcholine (ACh). Keratinocytes of the epidermis synthesize and release ACh. The uptake of choline is the rate-limiting step in both ACh synthesis and choline phospholipid metabolism, and it is a prerequisite for keratinocyte prol...

The purpose of the present study is to clarify the effects of the administration of choline on the in vivo release and biosynthesis of acetylcholine (ACh) in the brain. For this purpose, the changes in the extracellular concentration of choline and ACh in the rat striatum following intracerebroventricular administration of choline were determined using brain microdialysis. We also determined ch...

The effect of semicarbazide on the oxidation of choline by rat liver mitochondria was studied. Semicarbazide was used to prevent both further oxidation of betainealdehyde and product inhibition of choline dehydrogenase by the aldehyde. NAD did not stimulate choline-based respiration when semicarbazide was present to prevent the oxidation of enzymatically formed betainealdehyde. In contrast, NAD...

Introduction: Neoplastic processes are known to exhibit increased total choline (tCho) peak at H-MRS [1] together with increased transcription of genes encoding for transmembrane choline transporters and choline kinases [2, 3]. Authors have highlighted that choline kinase activity was unregulated contrarily to downward phosphocholine cytidyl transferase which may constitute a block allowing upw...

Choline is needed for the maintenance of the structural integrity and signaling functions of cell membranes, for neurotransmission, and for transport of lipids and as a source of methyl groups. Choline can be made de novo in the body, but some individuals must also obtain choline in the diet to prevent deficiency symptoms. A number of environmental and genetic factors influence dietary requirem...