نتایج جستجو برای: cholesterol ester transfer protein

تعداد نتایج: 1585710  

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2010
Laurent Yvan-Charvet Jelena Kling Tamara Pagler Hongna Li Brian Hubbard Tim Fisher Carl P Sparrow Andrew K Taggart Alan R Tall

OBJECTIVE To examine the effects of treatments with niacin or anacetrapib (an inhibitor of cholesteryl ester transfer protein) on the ability of high-density lipoprotein (HDL) to promote net cholesterol efflux and reduce toll-like receptor-mediated inflammation in macrophages. METHODS AND RESULTS A total of 18 patients received niacin, 2 g/d, for 4 weeks; 20 patients received anacetrapib, 300...

Journal: :Journal of Lipid Research 1993

2004
Paul C. Kuo

Abbreviations: bactericidal/permeability-increasing, (BPI); basic fibroblast growth factor, (bFGF); cardiac index, (CI); cholesterol ester transfer protein, (CETP); chromatin immunoprecipitation, (ChIP); c-Jun N-terminal kinase, (JNK); cyclic monophosphate, (cGMP); endothelial NOS, (eNOS); Gly-Arg-Gly-Asp-Ser, (GRGDS); glycosylphosphatidyinositol, (GPI); heterogeneous ribonucleoprotein A/B, (hn...

Journal: :Journal of lipid research 1997
H Chiba H Akita K Tsuchihashi S P Hui Y Takahashi H Fuda H Suzuki H Shibuya M Tsuji K Kobayashi

High density lipoprotein (HDL) with and without apolipoprotein (apo) E was quantified and characterized in subjects with three genotypes of cholesteryl ester transfer protein (CETP) deficiency: the nonsense mutation in intron 14 (10 homozygotes and 5 heterozygotes); the missense mutation in the exon 15 (3 homozygotes and 9 heterozygotes); and the Int14A/D442G in 6 compound heterozygotes. ApoE-p...

2017
Spencer Phillips Hey Jessica M. Franklin

Biomarkers are frequently proposed as a way of identifying targets and facilitating the evaluation of new drugs. When these chemical or genetic indicators are used as surrogate measures, the effects of drugs can be observed using smaller and shorter trials. However, even though biomarkers are based on plausible biological hypotheses, many end up failing to predict which drugs will later succeed...

Journal: :Circulation 2009
Hiroyuki Tanigawa Jeffrey T Billheimer Jun-ichiro Tohyama Ilia V Fuki Dominic S Ng George H Rothblat Daniel J Rader

BACKGROUND Lecithin:cholesterol acyltransferase (LCAT) catalyzes the formation of plasma cholesteryl ester, plays a key role in high-density lipoprotein metabolism, and has been believed to be critical in the process of reverse cholesterol transport (RCT). METHODS AND RESULTS The role of LCAT in RCT from macrophages was quantified with a validated assay involving intraperitoneal injection in ...

Journal: :Arteriosclerosis and thrombosis : a journal of vascular biology 1991
R McPherson C J Mann A R Tall M Hogue L Martin R W Milne Y L Marcel

Cholesteryl ester transfer protein (CETP) mediates an important pathway for reverse cholesterol transport. Concentrations of CETP in fasting plasma were measured by radioimmunoassay in two different groups of hyperlipoproteinemic subjects. Plasma CETP concentrations measured by radioimmunoassay correlated closely with cholesterol ester transfer activity in normal plasma (r = 0.86). In the first...

Journal: :Circulation 2002
Greetje J de Grooth Jan Albert Kuivenhoven Anton F H Stalenhoef Jacqueline de Graaf Aeilko H Zwinderman Jan L Posma Arie van Tol John J P Kastelein

BACKGROUND Cholesteryl ester transfer protein (CETP) mediates the transfer of neutral lipids between lipoproteins. High plasma levels of CETP are correlated with low HDL cholesterol levels, a strong risk factor for coronary artery disease. In earlier studies, JTT-705, a novel CETP inhibitor, was shown to increase plasma HDL cholesterol and to inhibit the progression of atherosclerosis in choles...

Journal: :Journal of lipid research 2003
Ilona Staprans Xian-Mang Pan Joseph H Rapp Kenneth R Feingold

The aim of this study was to determine in humans whether oxidized cholesterol in the diet is absorbed and contributes to the pool of oxidized lipids in circulating lipoproteins. When a meal containing 400 mg cholestan-5alpha,6alpha-epoxy-3beta-ol (alpha-epoxy cholesterol) was fed to six controls and three subjects with Type III hyperlipoproteinemia, alpha-epoxy cholesterol in serum was found in...

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