Chronic myelogenous leukemia (CML) blast crisis is an ominous clinical event that is challenging to treat. This can develop at extramedullary sites rarely and is defined as the infiltration of blasts outside the bone marrow irrespective of proliferation of blasts within the bone marrow. We aim to report an unusual clinical presentation characterized by Horner's syndrome, ipsilateral arm weaknes...

Granulocytic sarcoma (GS) is a rare extra medullary solid tumour composed of immature myeloid cells. These tumours often display a greenish colour due to the enzymatic action of myeloperoxidase in the tumour cells. Hence, the term 'chloroma' was given to this lesion in 1853. GS commonly involves bone, periosteum, soft tissue, lymph node, and skin. Rare occurrences in muscle, meninges, breast, m...

Leukemic involvement of the temporal bone is not uncommon and may present in a variety of ways including auricular or external canal skin lesions, red or thick tympanic membrane, middle ear effusions, otitis media, hearing loss or mastoiditis. Symptomatic facial nerve involvement, on the other hand, is extremely unusual. We discuss a pediatric patient whose sudden onset facial nerve paresis was...

A 67 year old man with myelodysplasia was admitted as an emergency with a six week history of rectal bleeding and diarrhoea. Barium enema showed an irregular polypoid filling defect in the lateral wall of the proximal rectum near the rectosigmoid junction. Histology showed this to be a granulocytic sarcoma (extramedullary granulocytic leukaemia; chloroma) infiltrating the bowel. A low index of ...

At the November meeting of the Edinburgh Medico-Chirurgical Society I exhibited a little boy suffering from that exceedingly rare disease?chloroma. The child subsequently succumbed to the disease, and I propose in the following remarks to give a record of the case, together with an account of the necropsy, and some notes of the interesting condition from which the boy suffered. J. D., aged 5 ye...

Introduction Myeloid sarcoma (previously chloroma or granulocytic sarcoma) is a very rare malignant neoplasm associated with myeloproliferative neoplasms. This type of tumour can be located anywhere outside the bone marrow. Aim To describe successful treatment and diagnostic myeloid sarcoma. Case study Retrospective case review. Results discussion paper presents in 50-year-old male. Patient pre...