Aim: Iminothiazolidinones are one of the important classes heterocyclic compounds and they occupied unique position in medicinal chemistry due to their wide range biological pharmaceutical properties. In view this potential activity, it has been planned synthesize a series New on benzimidazole nucleus study activity.
 Methodology: 1,1 dioxide- were synthesized with simple efficient method ...

The effects of dichloroacetate (DCA) and trichloroacetate (TCA) administered in drinking water were studied. At high concentrations of either compound, weight loss, or failure to gain weight, was observed. Food consumption was also decreased; both effects were attributed to decreased water consumption. Renal phosphate-dependent glutaminase activity was increased at the highest concentration, an...

Pseudomonas putida PP3 utilizes halogenated alkanoic acids (HAA) such as 2,2-DCPA as its sole carbon and energy sources. Spontaneous HHA- mutants, isolated by selection for resistance to the toxic analogs monochloroacetic acid and dichloroacetic acid, arose at frequencies several orders of magnitude higher than expected for spontaneous mutations. Analysis of the five classes of mutants isolated...