Endosulfan-alpha is metabolized to a single metabolite, endosulfan sulfate, in pooled human liver microsomes (Km = 9.8 microM, Vmax = 178.5 pmol/mg/min). With the use of recombinant cytochrome P450 (P450) isoforms, we identified CYP2B6 (Km = 16.2 microM, Vmax = 11.4 nmol/nmol P450/min) and CYP3A4 (Km = 14.4 microM, Vmax = 1.3 nmol/nmol P450/min) as the primary enzymes catalyzing the metabolism ...

Endosulfan (6,7,8,9,10,10-hexachloro-1,5,5a,6,9,9a-hexahydro6,9-methano-2,4,3-benzo-odioxa-thiepin-3-oxide) is a chlorinated cyclodiene insecticide which acts as a contact poison in a wide variety of insects and mites (Naqvi and Vaishnavi, 1993). Endosulfan was first registered for use in the USA in 1954 to control agricultural insects and mite pests. Due to its toxic effect, the World Health O...

For more than a decade, the MAPK (mitogen-activated protein kinase) cascade has been studied using mathematical modelling and quantitative experimentation [1]. The MAPK cascade relays the presence of extracellular stimuli such as growth hormones to the nucleus and controls the expression of hundreds of genes. MAPKs control major cell fate decisions such as proliferation, differentiation and apo...

Abstract: Objectives: Forced degradation study of the drug product and substance is very much important in development discovery to establish intrinsic stability understand its behaviors towards different stress conditions. In present work, testing neostigmine bromide (NBr) was carried out as per ICH guidelines identify characterize (DP) formed. Materials Methods: According guidelines, subjecte...

DLLME, which is a method that minimizes organic solvent consumption and waste generation, frequently used for trace analyte determination. In the present work, simple, selective sentsitive spectrophotometric based on dispersive liquid-liquid microextraction was reported. The procedure formation of 1:1 complex between Fe3+ water-soluble Cu(II) phthalocyanine then extraction this into dichloromet...

PURPOSE To characterize the optical coherence tomography angiography (OCTA) appearance of the perifoveal macular microvasculature in visually asymptomatic patients with sickle cell disease, and to compare these findings with those of fluorescein angiography (FA). DESIGN Retrospective observational case series. METHODS Eighteen eyes of 9 consecutive patients with a median age of 41 years (ra...

Endosulfan is an organochlorine insecticide and acaracide used to control a broad range of insect and arthropod pests on a wide variety of crops in many agrosystems. It can cause acute and chronic toxicity. Endosulfan is a neurotoxin, haematoxin, genotoxin and nephrotoxin. Toxicity of this insecticide on reproductive organs is confirmed. So this article reviews experimental and epidemiological ...

The genotoxic effect of endosulfan and the modulatory effect of vitamin C in growing albino rats were studied by bone marrow micronucleus assay. Seven days old male Wistar rats were treated with 3, 6, 9, 12mg/kg Endosulfan orally (10 pups/group),for up to 60 days, at intervals of 24h. For 2 more groups (n=10/group), Endosulfan 9mg/kg and 12mg/kg was administered along with vitamin C (20mg/kg). ...

Abstract In the manuscript, we discuss properties of SDSS J1042-0018 which is a broad line AGN but mis-classified as HII galaxy in BPT diagram (SDSS called AGN). The emission lines around H$\alpha$ and H$\beta$ are well described by different model functions, considering Balmer to be Gaussian or Lorentz functions. Different functions lead determined narrow fluxes, flux ratios diagram. order exp...