نتایج جستجو برای: chlamydia abortus

تعداد نتایج: 16924  

2018
María Virginia Gentilini Ayelén Ivana Pesce Viglietti Paula Constanza Arriola Benitez Andrea Elena Iglesias Molli Gloria Edith Cerrone Guillermo Hernán Giambartolomei María Victoria Delpino

Brucella abortus induces an inflammatory response that stimulates the endocrine system resulting in the secretion of cortisol and dehydroepiandrosterone (DHEA). Osteoarticular brucellosis is the most common presentation of the active disease in humans, and we have previously demonstrated that B. abortus infection inhibits osteoblast function. We aimed to evaluate the role of cortisol and DHEA o...

Journal: :Infection and immunity 2013
Jin Ju Lee Dong Hyeok Kim Dae Geun Kim Hu Jang Lee Wongi Min Man Hee Rhee Jae Youl Cho Masahisa Watarai Suk Kim

Brucella abortus is an intracellular pathogen that uses a crafty strategy to invade and proliferate within host cells, but the distinct signaling pathways associated with phagocytic mechanisms of B. abortus remain unclear. The present study was performed to test the hypothesis that Toll-like receptor 4 (TLR4)-linked signaling interacting with Janus kinase 2 (JAK2) plays an essential role in B. ...

Journal: :Journal of immunology 2012
Gaku Nakato Koji Hase Michio Suzuki Masanobu Kimura Manabu Ato Misaho Hanazato Minoru Tobiume Motohiro Horiuchi Ryuichiro Atarashi Noriyuki Nishida Masahisa Watarai Koichi Imaoka Hiroshi Ohno

Brucella abortus is a Gram-negative bacterium causing brucellosis. Although B. abortus is known to infect via the oral route, the entry site in the gastrointestinal tract has been unclear. We found that B. abortus was selectively internalized by microfold cells (M cells), a subset of epithelial cells specialized for mucosal Ag uptake. During this process, colocalization of cellular prion protei...

Journal: :Infection and immunity 2003
Bryan H Bellaire Philip H Elzer Sue Hagius Joel Walker Cynthia L Baldwin R Martin Roop

Brucella abortus reportedly produces the monocatechol siderophore 2,3-dihydroxybenzoic acid (2,3-DHBA) in response to iron limitation. Nucleotide sequence analysis of the cloned DHBA biosynthesis locus from virulent B. abortus 2308 and genetic complementation of defined Escherichia coli mutants were used to identify the B. abortus genes (designated dhbC, -B, and -A) responsible for synthesis of...

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