The separation of chiral compounds is an interesting and challenging topic in analytical chemistry, especially in environmental fields. Enantioselective degradation or bioaccumulation has been observed for several chiral pollutants. Polycyclic musks are chiral and are widely used as fragrances in a variety of personal care products such as soaps, shampoos, cosmetics and perfumes. In this study,...

represent high separation efficiencies, rapid analysis time, and low reagent consumption, they have been widely studied as promising analytical methodologies.1–4 Chiral separation is one of the major objectives in CE as well as in chromatographic methods. In these separations, a diverse range of CDs (cyclodextrins) have been employed as chiral additives including nonderivative CDs, derivative n...

The current situation of chiral drug development in Japan was investigated. The trend in the Japanese pharmaceutical development is increasingly moving towards the development of single isomers rather than racemates. The development of single-enantiomer drugs was made possible by the current technologies of asymmetric synthesis and chiral separation, and encouraged by the guidelines on the deve...

This review summarizes recent developments in chiral separation in capillary zone electrophoresis (CZE), electrokinetic chromatography (EKC), and capillary electrochromatography (CEC) covering literature published since the year 2000. New chiral selectors and innovative approaches for CE and CEC are introduced. Recent progress in column technology for CEC is highlighted and the development of n...

est, because the biologically effective chiral drug is either of enantiomers and the antipode is regarded as the impurity showing sometime high toxicity. Recently, the HPLC with chiral stationary phases (CSPs) has been extensively used to achieve the direct enantiomer separation. Crown ether, first introduced by Pedersen in 1967, was shown by Cram et al. to resolve enantiomers by the host-guest...

We investigate the influence of Kondo effect, namely, nonperturbative effect induced by heavy impurities, on chiral separation (CSE) in quark matter. employ a simple effective model incorporating condensate made light and quark, compute response function axial current to magnetic field static limit dynamical limit. As result, we find that catalyzes CSE both limits, particularly can be enhanced ...

Chiral, or asymmetric catalysis is the most efficient approach to chiral molecules in the enantiomerically enriched form. Organocatalysis and organometallic catalysis are nowadays the methods of choice in this field. In the first case enantiomerically pure chiral organic molecules of different symmetry classes exhibit catalytic effect, in the second one chiral organic molecule acts as the ligan...