We identified a patient with novel heterozygous variant fibrinogen, γp.C352R (Niigata II; N-II), who had bleeding episode and failed infertility treatment was suspected to have hypodysfibrinogenemia based on low discordant fibrinogen levels (functional assay 0.33 g/L, immunological 0.91 g/L). analyzed the mechanism of this rare phenotype congenital disorder. Patient plasma purified protein char...
