Cancer chemotherapeutic drugs acts in different manner to kill malignant cells. Most of the anticancer available clinical practice treat cancer patients, are natural products including whole plant extract, crude extracts, isolated constituents, –based drug formulations etc. These compounds have been a basis for development several against cancer. Agents such as topotecan, taxol, vinca alkaloids...

Autophagy usually functions in cell-protective events. However, it may also be utilized as a cell-suicide mechanism, which is known as “autophagic cell death.” Autophagic cell death is frequently induced in cells that lack apoptotic machinery, such as p53-defi cient cancer cells. Therefore, small compounds that activate autophagic cell death are good candidates for anticancer chemotherapeutics ...