BACKGROUND Aspirin chemoprevention combined with colonoscopy screening is not cost-effective for the general population. However, the cost-effectiveness of aspirin in individuals with prior adenoma resection has not been evaluated. AIM To evaluate the cost-effectiveness of aspirin chemoprevention alone and in combination with colonoscopy surveillance in patients with prior adenoma resection. ...

BACKGROUND Breast cancer can be prevented with selective estrogen receptor modifiers (SERMs) and aromatase inhibitors (AIs). The US Preventive Services Task Force recommends that women with a 5-year breast cancer risk ≥3% consider chemoprevention for breast cancer. More than 70 single nucleotide polymorphisms (SNPs) have been associated with breast cancer. We sought to determine how to best int...

The potential applicability of specific carcinogen-derived biomarkers in chemoprevention trials against lung and oral cancer is discussed. At present, there are no examples of the use of these biomarkers in chemoprevention trials, but the principle has been established in chemoprevention trials directed at aflatoxin B1-induced liver cancer. Polycyclic aromatic hydrocarbons (PAHs) and tobacco-sp...

Title of dissertation: EFFECT OF AGING ON COLONIC CHEMOPREVENTION BY DIETARY CURCUMIN Youngjoo Kwon, Doctor of Philosophy, 2006 Dissertation directed by: Assistant Professor Bernadene Magnuson Department of Nutrition and Food Science The incidence of cancer is highly dependent on age. The hypothesis of this thesis was that aging may alter the efficacy of dietary chemoprevention. This hypothesis...

The continued cancer risks associated with chronic inflammation necessitate the identification of inflammatory molecules and the cancer pathways they affect. Evidence indicates that there are multiple mechanisms linking inflammation to cancer and that there are multiple targets for chemoprevention. Here, we review some of the key factors and the cancer pathways they disturb as a necessary prere...

This paper proposes a collaborative methodology for developing semantic data models. The proposed methodology for the semantic model development follows a “meet-in-the-middle” approach. On the one hand, the concepts emerged in a bottom-up fashion from analyzing the domain and interviewing the domain experts regarding their data needs. On the other hand, it followed a top-down approach whereby e...

Adducts arise from the chemical modification of bases in DNA or amino acids in proteins by toxic chemicals. Many chemicals known to be carcinogenic in humans have been shown to form adducts or to cause oxidative damage to genomic DNA in model systems. Biomarkers of carcinogenesis reflect biological events that take place between exposure to external or endogenous carcinogens and the subsequent ...

The potential for chemical intervention (chemoprevention) as a means of halting or delaying the process of carcinogenesis is assessed as a strategy for reducing the incidence of human cancer. The process of carcinogenesis is dissected into its constituent steps, thereby exposing sites for intervention. These sites are then critically discussed with regard to the existence of chemicals active at...

1Biology Department, College of Science, UAE University, Al-Ain 17551, UAE 2Zoology Department, Faculty of Science, Cairo University, Cairo 12613, Egypt 3Department for Genetic Toxicology and Cancer Biology, National Institute of Biology, Večna Pot 111, Ljubljana, Slovenia 4Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA 5Experimental Tum...