This paper reports the first application of surface enhanced Raman chemical imaging on pharmaceutical tablets containing the active ingredient (API) in very low concentrations. Taking advantage of the extremely intensive Raman signals in the presence of silver colloids, image aquisition time was radically decreased. Moreover, the investigation of drug distribution below the detection limit of r...

BACKGROUND Mesenteric ischemia-reperfusion induces gut mucosal damage. Intestinal mucosal wounds are repaired by epithelial restitution. Although many different molecular mechanisms have been shown to affect cell metabolism under oxidative conditions, these molecular mechanisms and metabolic phenotypes are not well understood. Nuclear magnetic resonance (NMR) spectroscopic data can be used to s...

Near-infrared spectroscopy (NIRS) is a fast and non-destructive analytical method. Associated with chemometrics, it becomes a powerful tool for the pharmaceutical industry. Indeed, NIRS is suitable for analysis of solid, liquid and biotechnological pharmaceutical forms. Moreover, NIRS can be implemented during pharmaceutical development, in production for process monitoring or in quality contro...

The study on the shape evolution of metal nanoparticles (MNPs) is crucial to gain an understanding on controlling the shape and size of metal nanostructures. In this work, a detailed study on shape evolution of silver (Ag) nanospheres to nanoplates induced by hydrogen peroxide (H2O2) was performed. According to the growth mechanism of Ag nanoplates, the spectrophotometric method combined with c...

In viscose production, it is important to monitor three process parameters as part of the spin-bath in order to assure a high quality of the final product: the concentrations of H2SO4, Na2SO4 and ZnSO4. During on-line production these process parameters usually show a quite high dynamics depending on the fibre type that is produced. Thus, conventional chemometric models, kept fixed during the w...

In general, applications of metabonomics using biofluid NMR spectroscopic analysis for probing abnormal biochemical profiles in disease or due to toxicity have all relied on the use of chemometric techniques for sample classification. However, the well-known variability of some chemical shifts in 1H NMR spectra of biofluids due to environmental differences such as pH variation, when coupled wit...

This work describes the use of a multi-LED photometer for discrimination of mineral water samples, employing chromogenic reagents and chemometric techniques. Forty-five water samples (including 7 different brands of mineral water and samples of deionised, distilled and tap waters) were analysed in a monosegmented flow system, using three different chromogenic reagents (murexide, PAR and eriochr...

The paper presents practical utilization of an electronic nose prototype, based on the FIGARO semiconductor sensors, in fast classification of Polish honey types-acacia flower, linden flower, rape, buckwheat and honeydew ones. A set of thermostating modules of the prototype provided gradient temperature characteristics of barbotage-prepared gas mixtures and stable measurement conditions. Three ...