Marco Baggiolin i. M.D.; Bernhard Moser, and Ian Clark-Lewis I nterleukin-8 (IL-8) is the best known represemitative of’ a new class of chemsiotactic cytokines, miow called chemokines, which activate leukocytes, amid are widely studied because of their role as novel mediators of inflamnmation.’2 Two subfamiiies of chemokines are distinguished according to the arraisgemnent of the first two of f...

The chemokines are a family of small molecules that mediate cell migration, activation, differentiation, angiogenesis, and perhaps other functions. The chemokines have been classified by their amino acid composition, functional activity, and receptor binding properties. The chemokines receptors are 7 transmembrane G proteins and there is considerable redundancy in ligand specificity. The role o...

background chemokines play important roles in immune system activation against microbial infections. objectives the current study aimed to evaluate seminal levels of cxc chemokines cxcl1, cxcl9, cxcl10 and cxcl12 in chlamydia trachomatis infected patients. materials and methods the c. trachomatis infection was determined employing polymerase chain reaction (pcr)-based methods. seminal concentra...

Background: TNF-mediated fibroblast-like synoviocyte (FLS) activation is important for inflammation and joint destruction in rheumatoid arthritis (RA). The role of TNF-receptor 1 (TNFR1) FLS has thoroughly been characterized. functions TNFR2 are, however, largely unknown. Objectives: To investigate the contribution to FLS. Methods: RA-FLS were transfected with TNFR2-targeting siRNA pools transc...

Chemokines are a superfamily of potent leukocyte chemoattractant cytokines with a molecular weight of 8-12 kDa. Historically, many chemokines had more than one name until the 1999 Keystone Symposium on Chemokines, when a new nomenclature was introduced (Zlotnik & Yoshie, 2000). Chemokines have been subdivided into four subfamilies on the basis of the position of either one or two cysteine resid...