Gadolinium chelates, intended as intravenous contrast media for magnetic resonance imaging, have been regarded as nonnephrotoxic and recommended to replace iodinated contrast media in patients with azotemia who are undergoing digital subtraction angiography (DSA). High intraarterial doses (up to 220 mmol of gadodiamide) have been used, with a 40% incidence of nephropathy. The authors discourage...

Nephrogenic systemic fibrosis (NSF) is a fibrosing disorder that may develop in patients who have advanced reduction in renal function. A causal relation between gadolinium (Gd(3+))-based contrast agents (Gd-CA) and NSF is probable and is supported by the accumulating data in the literature. From those data, the prevalence of NSF is seen to be significantly higher after exposure to gadodiamide ...

The carcinogenic activities of s.c. administered N-hydroxy-2-acetylaminofluorene (N-hydroxy-AAF) and a variety of its metal chelates were investigated with reference to the time of exposure of the tissue to the compounds. No tumors were obtained at the sites of 4 injections of N-hydroxy-AAF (3.2 mg/injection), but 4 and 16 of 20 rats developed sarcomas at the sites of 8 and 16 injections, respe...

Marine microalgae support world fisheries production and influence climate through various mechanisms. They are also responsible for harmful blooms that adversely impact coastal ecosystems and economies. Optimal growth and survival of many bloom-forming microalgae, including climatically important dinoflagellates and coccolithophores, requires the close association of specific bacterial species...

The title ligand ('L') in crystalline [CuBrL(2)]Br.CH(3)OH and [Cu(OH(2))L(2)]SO(4).H(2)O.CH(3)OH chelates to both the copper(II) cations and the charge-balancing anions.

A new method of dispersive liquid-liquid microextraction (DLLME) combined with graphite furnace atomic absorption spectrometry (GFAAS) was proposed for the determination ultra-trace copper. It based on reaction Cu(II) laboratory-prepared chelating agent 2-(5-bromo-2-pyridylazo)-5-dimethylaminoaniline (5-Br-PADMA) in a HAc-NaAc buffer solution at pH 5.0 to form stable hydrophobic chelates, which...