Aims Rotherham Doncaster and South Humber (RDaSH) NHS Trust completed a Trust-wide audit in August 2021 to look at aspects of physical health management their inpatient units. Good results were achieved relation new admissions having initial medical examination within 24 hours consideration being given as whether the patient had capacity make decision agree or refuse such an examination. Howeve...

Synucleins are emerging as central players in the formation of pathologically insoluble deposits characteristic of neurodegenerative diseases. synuclein (SNCG), previously identified as a breast cancer-specific gene (BCSG1), is also highly associated with breast or ovarian cancer progression. However, the molecular targets of SNCG aberrant expression in breast cancer have not been identified. H...

ABSTRACT Ribulose 1,5-bisphosphate carboxylase/oxygenase (Rubisco) is present in all photosynthetic organisms and a key enzyme for photosynthesis-driven life on Earth. Its most prominent form hetero-oligomer which small subunits (SSU) stabilize the core of built from large (LSU), yielding, after chaperone-assisted multistep assembly process, an LSU8SSU8 hexadecameric holoenzyme. Here we use Chl...

Background: A novel chaperone, cpSRP43, recognizes and disassembles the aggregates formed by its client proteins. Results: The client proteins of cpSRP43 form stable disc-shaped aggregates with the chaperone recognition motif displayed on the surface. Conclusion: The surface-exposed motif on the aggregate allows it to be recognized by its chaperone. Significance: Understanding the structure and...

Madam We fail to understand why Dr Stephen Searle1 feels that implementing the Faculty’s Service Standards2 should detract from our level of client care. If a service has a clear chaperone policy or protocol then the amount of actual documentation required is minimal. An entry in the case notes ‘chaperone declined’ or ‘chaperone: Nurse Smith’ should suffice to indicate adherence with the policy...