Background Chromium (Cr) supplements used as “magic lift” without authentications and Cr contaminated sewage water cultivate vegetables and crops around the vicinity of big cities. It is scientific responsibility to find out the toxic effects and preventive measures against such pollutants by local cheapest sources. Testicular histopathology of hexavalent chromium (Cr+6) was investigated in adu...

Purpose: Although cetuximab, an anti-EGF receptor (EGFR) monoclonal antibody, is an effective treatment for patients with KRAS wild-type metastatic colorectal cancer (mCRC), its clinical use is limited by onset of resistance. Experimental Design: We characterized two colorectal cancer models to study the mechanisms of acquired resistance to cetuximab. Results: Following chronic treatment of nud...

In most hematologic malignancies the role of induction treatment is to achieve complete remission (CR). In multiple myeloma this has been possible only with the introduction of high-dose therapy plus autologous stem-cell transplantation (ASCT). In the context of ASCT there is a statistical relationship between CR or very good partial remission (VGPR) achievement and progression-free survival or...

BACKGROUND Arginine:glycine amidinotransferase deficiency (AGAT-d) is a very rare inborn error of creatine synthesis mainly characterized by absence of brain Creatine (Cr) peak, intellectual disability, severe language impairment and behavioural disorder and susceptible to supplementary Cr treatment per os. Serial examinations by magnetic resonance spectroscopy are required to evaluate Cr recov...

In this proton magnetic resonance spectroscopy ((1)H-MRS) study, the authors correlated cognitive improvement after 3 months of treatment with donepezil with changes of N-acetylaspartate (NAA) level and NAA/Creatine (Cr) ratio in the medial temporal and parietal lobe of 17 patients with Alzheimer disease. Treatment response was associated with an increase of NAA and NAA/Cr in the parietal lobe....

OBJECTIVES To determine if caloric restriction (CR) would cause changes in plasma metabolic intermediates in response to a mixed meal, suggestive of changes in the capacity to adapt fuel oxidation to fuel availability or metabolic flexibility, and to determine how any such changes relate to insulin sensitivity (S(I)). METHODS Forty-six volunteers were randomized to a weight maintenance diet (...

Compositions with tie lines between the and ( ; ) phases in a ternary Re-Cr-Ni system were investigated by heat treating various ternary Re-Cr-Ni alloys at 1573K in vacuum for up to 2000 h. The microstructures of the Re-containing alloys that had been water quenched after various heat treatment for times were observed and their concentration profiles for Re, Cr, and Ni were measured using an el...

Cognitive radio (CR) technology has been suggested for effective use of spectral resources. Spectrum sensing is one of the main operations of CR users to identify the vacant frequency bands. Cooperative spectrum sensing (CSS) is used to increase the performance of CR networks by providing spatial diversity. The accuracy of spectrum sensing is the most important challenge in the CSS process sinc...

BACKGROUND AND PURPOSE Brain creatine (Cr) deficiencies (BCr-d) are rare disorders of creatine biosynthesis and transport. We performed consecutive measures of total Cr (tCr) and of its phosphorylated fraction, phosphocreatine (PCr), in the brains of children affected by Cr synthesis defects during a long period of therapy. The aim was to identify the optimal treatment strategy for these disord...

Herein we present a new approach for the complete removal of Cr(VI) species, through reduction of Cr(VI) to Cr(III), followed by adsorption of Cr(III). Reduction of chromium from water is an important challenge, as Cr(IV) is one of the most toxic substances emitted from industrial processes. Chitosan (CS) thin films were developed on plain polysulfone (PSf) and PSf/TiO2 membrane substrates by a...