Adenosine A1 receptors were characterized in membranes from rat dorsal and ventral spinal cord using [3H] cyclohexyladenosine [( 3H]CHA) and compared with those in brain. For determination of anatomical loci of adenosine A1 receptors in the dorsal and ventral spinal cord, various lesions were employed, including kainic acid injections directly into the lumbar dorsal spinal cord, spinal cord hem...

It is now well established that bile acids act as colon tumor promoters. However, a previous study provided conflicting data showing that dietary exposure of cholic acid (CHA), a primary bile acid, inhibits the carcinogen-induced formation of aberrant crypt foci (ACF), possible preneoplastic lesions, in colonic mucosa of rodents. Recently we found beta-catenin-accumulated crypts (BCAC) in colon...

OBJECTIVES To evaluate the individual risk factors composing the CHADS(2) (Congestive heart failure, Hypertension, Age ≥ 75 years, Diabetes, previous Stroke) score and the CHA(2)DS(2)-VASc (CHA(2)DS(2)-Vascular disease, Age 65-74 years, Sex category) score and to calculate the capability of the schemes to predict thromboembolism. DESIGN Registry based cohort study. SETTING Nationwide data o...

We give formal content to some concepts, naturally stemming from consistent history approach (CHA), which are not formalized in the standard formulation of the theory. The outcoming (extended) conceptual basis is used to perform a formal, conceptually transparent analysis of some debated questions in CHA. As results, the problems raised by contrary inferences of Kent are ruled out, whereas some...

In C. elegans, the gene cha-1 is the structural gene for choline acetyltransferase, the enzyme which synthesizes acetylcholine. cha-1 is a complex gene which includes the previously described unc-17 locus; it has been hypothesized that a single protein is encoded which consists of several discrete structural domains. Mutations of the cha-1-unc-17 locus can be assigned to one of four classes on ...

1. CHA, S., MOURAD, N., CHA, C.-J. M., AND PARKE, R. E., JR., Fedemtion Proc., 24, 362 (1965). 2. MITCHELL, R. A., BUTLER, L. G., AND BOYER, P. D., B&hem. and Biophys. Research Communs., 16, 545, (1964). 3. KREIL, G., AND BOYER, P. D., Biochem. and Biophys. Research Commune., 16, 551 (1964). 4. CHA, S., AND PARKS, R. E., JR., Federation Proc., 22, 361 (1963); J. Btil. Chem., 239, 1961 (1964). 5...

Nitrogen oxides (NOx) are formed during combustion in diesel engines and one current approach to reduce NOx to N2 is selective catalytic reduction with NH3 as reducing agent (NH3-SCR). To acquire both high activity and selectivity, the active site is often atomically dispersed metal atom, so-called single-site catalysts. In the case of NH3-SCR, one example is Cu-exchanged chabazite (Cu-CHA). Th...

In this study the role of adenosine A1 receptors of the CA1 region of hippocampus on piriform cortex–kindled seizures was investigated in rats. Obtained results showed that in kindled animals, bilateral microinjection of N6–cyclohexyladenosine (CHA), an adenosine A1 receptor agonist, at doses of 10 and 100 mM into the hippocampal CA1 region decreased the afterdischarge duration (ADD), stage 5 s...