Background: Infertility problem affects 20-30% of young couples. One of the known causes of spermatogenesis disorder is chemotherapy in patients with cancer which its side effect may last up to the end of the life. Since dividing cells are mainly affected by anticancer drugs, the aim of the present study is to investigate the preventive effect of GnRH on spermatogenic defect produced by antican...

Background: Male factors, mainly spermatogenesis disorder, are responsible for 20-30% of infertility occurs in different societies. One of the known causes of spermatogenesis disorder is chemotherapy in patients with cancer. The side effect of chemotherapic agents may last from 10 years up to the end of the life. Since dividing cells are mainly affected by anticancer drugs, the aim of the prese...

background: gonadotropin-releasing hormone (gnrh) plays essential roles in embryo implantation, invasion of trophoblastic tissue, and steroid synthesis in the placenta. objective: the aim of this study was to evaluate the effect of gnrh antagonist administration on pregnancy outcomes in early implantation period. materials and methods: in this retrospective study, 94 infertile women undergoing ...

the aim of this study was to evaluate the outcomes of adding low-dose hcg (human chorionic gonadotropin), as an lh active supplement, to a gnrh antagonist protocol in patients undergoing assisted reproduction techniques. in this parallel-group randomized clinical trial, 137 infertile female outpatients aged 20 - 39 years were randomized into two groups: hcg group and non-hcg group. all patients...

To address whether gonadotropin-releasing hormone (GnRH) regulates its own expression and the expression of its receptor in the hypothalamus and ovary, we treated five groups of prepubertal/peripubertal female rats from postnatal days 25-36 with either the GnRH agonist triptorelin (TRIP) or the GnRH antagonist cetrorelix (CET), each 10 or 100 microgram/day, or a placebo. We compared their effec...

offers many advantages as newly designed drugs. The benefits include enhanced stability to proteolytic enzymes, better transport through cellular membranes, increased bio-availability, changing agonist to antagonists potency and higher affinity in ligand-receptors interactions. D-amino acids are used to design and obtain new peptidomimetics by their incorporation in place of the natural L-amino...

Background: Male factors, mainly spermatogenesis disorder, are responsible for 20-30% of infertility occurred in different societies. One of the known causes of spermatogenesis disorder is chemotherapy in patients with cancer. The side effect of chemotherapic agents may last from 10 years up to the end of the life. Since dividing cells are mainly affected by anticancer drugs, the aim of the pre...