Small cell carcinoma of the uterine cervix is rare. It is estimated that 10% of patients with small-cell lung cancer have syndrome of inappropriate secretion of antidiuretic hormone (SIADH) and hyponatremia has been reported to be significantly associated with a poor prognosis. A proportion of small cell carcinoma of the uterine cervix exhibit neuroendocrine characteristics as revealed by immun...

Bilateral neurectomy of the pelvic nerve (BLPN) that carries uterine cervix-related sensory nerves induces dystocia, and administration of its vasoactive neuropeptides induces changes in the cervical microvasculature, resembling those that occur in the ripening cervix. This study was designed to test the hypothesis that (a) the cervix of pregnant rats expresses vascular endothelial growth facto...

As the critical gatekeeper for birth, prepartum remodeling of the cervix is associated with increased resident macrophages (Mφ), proinflammatory processes, and extracellular matrix degradation. This study tested the hypothesis that expression of genes unique to Mφs characterizes the prepartum from unremodeled nonpregnant cervix. Perfused cervix from prepartum day 21 postbreeding (D21) or nonpre...

Gastrin-releasing peptide (GRP) has been suggested as a novel regulatory peptide in the female reproductive tract but the presence of GRP and GRP mRNA in the non-neurogenic tissue of the cervix has not yet been clarified. In the present study, immunohistochemistry and in situ hybridization were used to reveal the distribution of GRP immunoreactivity and expression of GRP mRNA in the bovine cerv...

Alveolar soft part sarcoma (ASPS) is a tumor of unknown histogenesis, composed of large, epithelioid cells with eosinophilic cytoplasm, having an alveolar pattern. Primary ASPS of uterine cervix is very rare. In this report, we present a 21-aged-old female with primary ASPS in the uterine cervix and discuss the clinicopathological characteristics, immunophenotype, molecular genetic feature and ...

Abnormal looking cervix, or suspicious cervix, is a common clinical condition seen in gynecological practice. Colposcopic examination of the cervix allows differentiation between physiologic changes that occur in response to normal cyclic variations in hormone secretion and a variety of structural and pathological conditions. This article addresses some of these common clinical problems and pro...

Squamous cell carcinoma of endometrium is diagnosed as primary of endometrium if it meets the Fluhmann and Kay criteria [3,4] i.e. absence of concomitant endometrial adenocarcinoma, no continuity between endometrial tumour and stratied squamous epithelium of cervix, no primary carcinoma cervix and if cervix shows carcinoma insitu , there must be no connection between this and independent endom...

Carcinoma cervix was a leading cause of death in women in USA, fifty years ago. Terris and Oalmam and Ratkinhave repeatedly demonstrated a relationship between several parameters of sexual activity and carcinoma cervix. Epidemiological data suggested a sexually transmitted agent as risk factor based on, early age at first intercourse, multiple sexual partners and a male partner with multiple se...

Cervical cancer incidence and mortality have decreased dramatically over the past 50 years in countries with access and resources to provide frequent screening, evaluation, and treatment of high-grade cervical cancer precursors. For countries with fewer resources and many competing health concerns, cervical cancer remains one of the most lethal and common cancers among women. With the advent of...