OBJECTIVE To evaluate the existence of an association between cervicovaginal infections and precancerous lesions of the uterine cervix, through determination of prevalent cervicovaginal micro-organisms, alone and in association with human papillomavirus (HPV), in patients with abnormal and normal vaginal cytology. PATIENTS AND METHODS Patients with abnormal vaginal cytology were divided into ...

The complete genome sequences of three novel Saimiri sciureus papillomavirus (SscPV) types (SscPV1 to SscPV3) isolated from the cervicovaginal region of squirrel monkeys were characterized. These three PV types share 78.1 to 83.3% nucleotide sequence identities with each other across the complete L1 open reading frame and cluster in the genus Dyoomikronpapillomavirus.

Cancer vaccine boost via the cervicovaginal rather than the intramuscular route of immunization appears to be crucial to induce genital CD8(+) T cells and tumor regression. This clinical activity is correlated with the ability of the mucosal boost to elicit resident memory T cells in the genital tract.

Vaginal dilation is proposed as the first choice treatment for patients with vaginal aplasia, but many patients with MRKH or Rokitansky syndrome (and cases with CAIS) may require a vaginoplasty. It is also necessary to make vaginoplasty in patients with vaginal or cervicovaginal atresia with a functional uterus before performing an utero-neovaginal anastomosis, also in trans-sexual men.