Spatial frequency spectra from cervical intraepithelial neoplasia (CIN) tissues are used to detect differences among different grades of human cervical tissues. The randomness of the structures of tissues from normal to different stages of CIN tissues is recognized by analyzing the spatial frequency. This study offers a simpler and better way to recognize the alterations among normal and differ...

Background: Cervical carcinoma is the most common cancer with a prevalence of 28.6% all cancers in women Indonesia and one leading causes death among gynecologic malignancies. Prevention understanding are needed terms initiation development precancerous lesions into cervical cancer. About 90% squamous cell carcinomas that develop from intraepithelial neoplasia. Epidermal Growth Factor Receptor ...

BACKGROUND Treatment decisions for cervical cancer, a common disease worldwide, depend on demonstrating whether or not tumor invasion of the surrounding tissue has occurred. Invasion can be difficult to assess by standard histopathologic methods, especially when limited amounts of tissue are available. Several studies of a variety of cancers have reported increased expression of laminin-5-an im...

Human leukocyte antigens (HLAs) present foreign antigens to the immune system and may be important determinants of cervical neoplasia. Previously published associations between HLA and cervical neoplasia exhibit considerable variation in findings. The biomarkers of cervical cancer risk (BCCR) case-control study addressed the role of specific HLA alleles as cofactors in the development of high-g...

The reproducibility of cervical histology diagnoses is critical for efficient screening and to evaluate the effectiveness of new technologies. The vast majority of cervical intraepithelial neoplasia (CIN) diagnoses reported in the New Technologies for Cervical Cancer study were blindly reviewed by 2 independent pathologists. Only H&E-stained slides were used for the review. The reviewers were a...

BACKGROUND/AIM Diagnostic procedures during the detection of cervical intraepithelial lesions (CIN) are a combination of cytology, colposcopy, punch biopsy and endocervical curretage. An optimal therapeutic approach according to the distribution, size and grade of cervical lesions is the result of this diagnostic protocol. This study was carried out to assess reliability of the punch biopsy and...

Early epidemiological studies of cervical neoplasia suggested a causal relation with sexual activity and human papillomaviruses (HPVs) have emerged as prime suspects as venerally transmitted carcinogens. HPVs fall into two broad camps: low risk types, associated with cervical condylomas and CIN 1; and high risk types (mostly 16 and 18), found in 50-80% of CIN 2 and CIN 3 lesions, and 90% of can...

The chemokine CXCL12 is highly expressed in gynecologic tumors and is widely known to play a biologically relevant role in tumor growth and spread. Recent evidence suggests that CXCL16, a novel chemokine, is overexpressed in inflammation-associated tumors and mediates pro-tumorigenic effects of inflammation in prostate cancer. We therefore analyzed the expression of CXCL12 and CXCL16 and their ...

Copyright © 2012. Korean Society of Obstetrics and Gynecology Bacterial vaginosis (BV) is common, treatable condition, where the normal Döderlein-dominated vaginal flora is replaced by other, predominantly anaerobic flora. Previous studies which have examined the relationship between BV and cervical intraepithelial neoplasia (CIN) gave conflicting conclusions with different results which ranged...