conclusions the results of the present investigation suggest that sac could be used as a food supplement in the treatment of diabetes characterized by provoked antioxidant status, altered blood glucose, and hormones level. results the levels of glucose, cyp2e1 activity, thiobarbituric acid reactive substances (tbars), hydroperoxide, and ceruloplasmin were increased significantly; whereas, the l...

Background: A crucial step in modifying the course of lupus nephritis is early identification kidney disease systemic patients. Lupus affects around 30% to 60% SLE patients and 70% juvenile SLE. Renal biopsy, which an invasive procedure with hazards, considered gold standard diagnose Nephritis. Ceruloplasmin (CP) acute phase protein that transports most circulating copper functions as iron oxid...

In a study of diet and early breast cancer, blood plasma copper has been analyzed by Proton Induced X-ray Emission analysis as both total copper (P-Cu) and that ultrafiltrable from plasma (P-edu-Cu) through membranes with a cut-off at molecular mass 10,000 after equilibration with disodium ethylene diamine tetraacetic acid (EDTA) at 4 degrees C. Ceruloplasmin (P-cer) was also measured using nep...

We report here on the characterization of a mutation in the ceruloplasmin gene in a 45 year old woman with insulin-dependent diabetes mellitus who presented with the recent onset of gait disturbance and dysarthria. Physical examination revealed an ataxic gait, scanning speech and retinal degeneration. Magnetic resonance imaging of the brain was consistent with increased basal ganglia iron conte...

BACKGROUND/AIMS A low serum ceruloplasmin level is considered a diagnostic test for Wilson's disease. To examine whether it is useful to detect presymptomatic patients with Wilson's disease, serum ceruloplasmin was determined by radial immunodiffusion (normal: 20-60 mg/dl) in all patients (n = 2867) admitted for evaluation of a liver disease in 1993 and 1994. METHODS Patients with levels lowe...

Cartilage matrix glycoprotein (CMGP) is a disulfide-bonded 550,000-dalton protein that is synthesized by chondrocytes and ciliary epithelial cells. We have purified the protein from bovine and porcine articular cartilage and have sequenced two peptides, which both have significant homology with human ceruloplasmin, a copper-binding oxidase. Immunolocation analysis indicates that a commercial po...

The research involved study the relation between FGF23 and some of biochemical parameters related to chronic kidney disease (Glutathion GSH arylesterase ARE enzymes,ceruloplasmin ,Malondialehyde ,glucose ,cholesterol ,triglyceride ,LDL ,VLDL,HDL)in serum blood patients compared with control group,the result demonstration is a significant increase in mean concentration rate was (324.06± 291.1 pg...

143) were transported 2,200 km to central Oklahoma. As an estimate of inflammation, concentrations of ceruloplasmin, fibrinogen, and haptoglobin were measured in blood samples collected at weaning, 24 and 72 h post-weaning, and on the day of shipping, 24 and 72 h after arrival. Fixed effects were breed type (n = 9 levels: straightbreds [RR, AA, BB], and crossbreds [RA, AR, RB, BR, AB, BA] where...

This study evaluated the effects of ceruloplasmin, the copper-containing blue oxidase of vertebrate plasma, on the relaxation of rabbit aortic rings after endothelial release of nitric oxide (NO). Ceruloplasmin at physiological, i.e., micromolar, concentrations inhibited relaxation of rabbit aorta induced by endothelium-dependent agonists like acetylcholine or ADP, whereas it was ineffective to...

LOOD OXIDASES HAVE BEEN DESCRIBED and discussed since 1912 based on tedious, elaborate means for the determination of their activity. The physiologic significance of oxidase activity has been implicitly associated with the blue copper protein of plasma designated as ceruloplasmin (1, 2, 3, 4, 5, 6). There appears to be a need for a simple, rapid procedure for the determination of ceruloplasmin ...