Cerebrovascular disease has been ranked the second or third of top 10 death causes in Taiwan and has caused about 13,000 people death every year since 1986. Once cerebrovascular disease occurs, it not only leads to huge cost of medical care, but even death. All developed countries in the world put cerebrovascular disease prevention and treatment in high priority, and invested considerable budge...

Neurofibromatosis type 1 is a multisystem genetic disease of autosomal dominant transmission that reveals important cutaneous manifestations such as café-au-lait spots, multiple neurofibromas, and ephelides in skin fold areas, as well as hamartomatous lesions in the eyes, bones, glands, and central nervous system. Moyamoya disease is a rare progressive vaso-occlusive disorder that occurs with i...

Cerebrovascular dysfunction is re-emerging as a major component of aging, and may contribute to the risk of developing Alzheimer's disease (AD). Two important risk factors for cerebrovascular dysfunction are APOE and female sex, which are primarily researched in the context of high amyloid-β (Aβ) levels as found in AD. However, APOE4 and sex modulate Aβ-independent pathways that may induce cere...

Introduction: Concurrent atherosclerosis of the intracranial and extracranial cerebrovascular system is common in Asians . Atherosclerotic diseases occurring in carotid arteries and intracranial arteries have been demonstrated to be associated transient ischemic attack (TIA) and stroke . Recently, Black-blood magnetic resonance imaging (MRI) has been increasingly applied for assessment of the c...

Cerebrovascular dysfunction is detected prior to the onset of cognitive and histopathological changes in Alzheimer's disease (AD). Increasing evidence indicates a critical role of cerebrovascular dysfunction in the initiation and progression of AD. Recent studies identified the mechanistic/mammalian target of rapamycin (mTOR) as a critical effector of cerebrovascular dysfunction in AD. mTOR has...

A neuroinvasive respiratory coronavirus, SARS-CoV-2 causes a variety of neurological responses in patients. These include dizziness, headache, myalgias, hypogeusia, hyposmia, polyneuropathy, myositis, cerebrovascular disease, encephalitis and encephalopathy. Such susceptibility the central nervous system (CNS) to virus has spurred interest neuropsychological research COVID-19 patients convalesc...

Cerebrovascular disease and vascular risk factors are associated with Alzheimer's disease, but the evidence for their association with other neurodegenerative disorders is limited. Therefore, we compared the prevalence of cerebrovascular disease, vascular pathology and vascular risk factors in a wide range of neurodegenerative diseases and correlate them with dementia severity. Presence of cere...