Tuberculosis is a formidable disease worldwide because of its highly infectious nature and propensity for latency. The increasing prevalence of tuberculosis in both immunocompetent and immunocompromised individuals in recent years makes this disease a topic of universal concern. The disease has insidious onset and can affect virtually any organ system in the body, including the central nervous ...

, SlR,—We read with interest the article by Dr Nesbit and others (June 27, p. 1386) on isolated central nervous system acute lymphocytic leukaemia in children. In this very helpful article Nesbit et aL state that "CNS relapse rates are lower in patients receiving effective treatment before CNS symptoms arise, but the bone marrow relapse rate was not significantly affected by prophylactic ...

Degenerative diseases of the nervous system in children are acknowledged to be chronic (usually) and destructive (invariably), and for the biochemically oriented clinician they provide a challenging interest because most are genetically, and probably, therefore, chemically determined. Individually relatively rare, most of them are inherited as autosomal recessive conditions, and by implication ...

Tuberculosis (TB) has shown a resurgence in nonendemic populations in recent years and accounts for 8 million deaths annually in the world. Central nervous system involvement is one of the most serious forms of this infection, acting as a prominent cause of morbidity and mortality in developing countries. The rising number of cases in developed countries is mostly attributed to factors such as ...

Lipoprotein and cholesterol metabolism in the brain involves metabolic pathways that are regulated independently of those in the peripheral circulation and tissues. The blood–brain barrier (BBB) restricts plasma lipids, including cholesterol and plasma lipoproteins, from entering or leaving the central nervous system (CNS). In the CNS, cholesterol is synthesized by astrocytes, oligodendrocytes,...

Systemic Lupus Erythematosus (SLE) is a complex clinical syndrome which its components are less clearly recognized and includes heterogeneous demonstrations engaging both central and peripheral nervous system along with disabling effects. This disease is called "thousand faces" due to these heterogeneous demonstrations. This gap exists while 75% of adults and children with SLE may dea...

Involvement of the central nervous system (CNS) by Mycobacterium tuberculosis, particularly meningitis, is the most severe form of tuberculous infection. Parenchymal CNS involvement can occur in the form of tuberculoma or, more rarely, abscess. Although surgery was initially advocated as the mainstay of therapy, more recent evidence suggests that parenchymal forms of CNS tuberculosis can be cur...

Primary and metastatic tumors of the central nervous system are a heterogeneous group of neoplasms with varied outcomes and management strategies. Recently, improved survival observed in 2 randomized clinical trials established combined chemotherapy and radiation as the new standard for treating patients with pure or mixed anaplastic oligodendroglioma harboring the 1p/19q codeletion. For metast...

Central nervous system involvement with malignant lymphoma whether primary or secondary is an uncommon but not rare complication observed in the management of patients with hematological malignancy. Its importance lies in the considerable morbidity and mortality with which it is associated and the inadequacy of therapy. In Section I, Dr. Lauren Abrey addresses the totality of the problem of pri...