Protein misfolding is a central feature of most neurodegenerative diseases. Molecular chaperones can modulate the toxicity associated with protein misfolding, but it remains elusive which molecular and co-chaperones interact specific misfolded proteins. TDP-43 inclusion formation are hallmark amyotrophic lateral sclerosis (ALS) other Using yeast mammalian neuronal cells we find that Hsp90 its c...

Nanotherapeutics utilize the properties of nanomaterials to alter pharmacology drugs and therapies being transported, leading changes in their biological disposition (absorption, distribution, cellular uptake, metabolism elimination) ultimately, pharmacological effect. This provides an opportunity optimize drugs, particularly for those that are dependent on hepatic action. Old age is associated...

A quantum dot (QD) conjugated whole-cell E. coli biosensor (E. coli–QD bioconjugates) was developed as a new molecular tool for probing cellular damage. The E. coli–QD bioconjugates were viable and exhibited fluorescence emission at 585 nm. Scanning electron microscopy (SEM) analysis of E. coli–QD bioconjugates revealed that the QDs were immobilized on the cell-surfaces and the fluorescence emi...

Catharanthus roseus is a medicinal and ornamental plant with growing attention toward its economical value. Cell suspension from C. roseus were treated with 0 to 60mM of cadmium nitrate for 1, 3 and 6 days, then cell viability was determined using trypan blue and MTT assay. Cell morphology was investigated using 0, 10, 30 and 50 mM of cadmium nitrate as selected dose for 3 days. Callus of C.ros...